{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:56:59Z","timestamp":1777503419161,"version":"3.51.4"},"reference-count":80,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000191","name":"Kidney Foundation of Canada","doi-asserted-by":"publisher","award":["852040-21KHRG"],"award-info":[{"award-number":["852040-21KHRG"]}],"id":[{"id":"10.13039\/501100000191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Kidney Health Dis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Emerging data favor central blood pressure (BP) over brachial cuff BP to predict cardiovascular and kidney events, as central BP more closely relates to the true aortic BP. Considering that patients with advanced chronic kidney disease (CKD) are at high cardiovascular risk and can have unreliable brachial cuff BP measurements (due to high arterial stiffness), this population could benefit the most from hypertension management using central BP measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the feasibility and efficacy of targeting central BP as opposed to brachial BP in patients with CKD G4-5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Pragmatic multicentre double-blinded randomized controlled pilot trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Seven large academic advanced kidney care clinics across Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>A total of 116 adults with CKD G4-5 (estimated glomerular filtration rate [eGFR] &lt; 30 mL\/min) and brachial cuff systolic BP between 120 and 160 mm Hg. The key exclusion criteria are 1) \u2265 5 BP drugs, 2) recent acute kidney injury, myocardial infarction, stroke, heart failure or injurious fall, 3) previous kidney replacement therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Double-blind randomization to a central or a brachial cuff systolic BP target (both &lt; 130 mm Hg) as measured by a validated central BP device. The study duration is 12 months with follow-up visits every 2 to 4 months, based on local practice. All other aspects of CKD management are at the discretion of the attending nephrologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes:<\/jats:title>\n                    <jats:p>Primary Feasibility: Feasibility of a large-scale trial based on predefined components. Primary Efficacy: Carotid-femoral pulse wave velocity at 12 months. Others: Efficacy (eGFR decline, albuminuria, BP drugs, and quality of life); Events (major adverse cardiovascular events, CKD progression, hospitalization, mortality); Safety (low BP events and acute kidney injury).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations:<\/jats:title>\n                    <jats:p>May be challenging to distinguish whether central BP is truly different from brachial BP to the point of significantly influencing treatment decisions. Therapeutic inertia may be a barrier to successfully completing a randomized trial in a population of CKD G4-5. These 2 aspects will be evaluated in the feasibility assessment of the trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This is the first trial to evaluate the feasibility and efficacy of using central BP to manage hypertension in advanced CKD, paving the way to a future large-scale trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>clinicaltrials.gov (NCT05163158)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20543581231172407","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T05:17:58Z","timestamp":1683350278000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["CENtral blood pressure Targeting: a pragmatic RAndomized triaL in advanced Chronic Kidney Disease (CENTRAL-CKD): A Clinical Research Protocol"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-3735","authenticated-orcid":false,"given":"R\u00e9mi","family":"Goupil","sequence":"first","affiliation":[{"name":"Hopital du Sacr\u00e9-Coeur de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7755-1404","authenticated-orcid":false,"given":"Annie-Claire","family":"Nadeau-Fredette","sequence":"additional","affiliation":[{"name":"Hopital Maisonneuve-Rosemont, Universit\u00e9 de Montr\u00e9al, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1139-4821","authenticated-orcid":false,"given":"Bhanu","family":"Prasad","sequence":"additional","affiliation":[{"name":"Regina General Hospital, SK, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3559-3531","authenticated-orcid":false,"given":"Gregory L.","family":"Hundemer","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-3927","authenticated-orcid":false,"given":"Rita S.","family":"Suri","sequence":"additional","affiliation":[{"name":"McGill University Health Centre, McGill University, Montr\u00e9al, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3030-8703","authenticated-orcid":false,"given":"William","family":"Beaubien-Souligny","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Agharazii","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Qu\u00e9bec, Universit\u00e9 Laval, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,6]]},"reference":[{"key":"bibr1-20543581231172407","unstructured":"Statistics Canada. Mortality, summary list of causes: 2009 (catalogue no.84F0209X). http:\/\/www.statcan.gc.ca\/pub\/84f0209x\/84f0209x2009000-eng.pdf. Published 2012. Accessed April 21, 2023."},{"key":"bibr2-20543581231172407","volume-title":"The Canadian Heart Health Strategy: Risk Factors and Future Cost Implications Report","author":"Conference Board of Canada","year":"2010"},{"issue":"9","key":"bibr3-20543581231172407","first-page":"997","volume":"19","author":"Manuel DG","year":"2003","journal-title":"Can J Cardiol"},{"key":"bibr4-20543581231172407","unstructured":"Public Health Agency of Canada. Tracking heart disease and stroke in Canada. http:\/\/www.phac-aspc.gc.ca\/publicat\/2009\/cvd-avc\/pdf\/cvd-avs-2009-eng.pdf. Published 2009. Accessed April 21, 2023."},{"key":"bibr5-20543581231172407","volume-title":"Canadian Organ Replacement Register Annual Report: Treatment of End-Stage Organ Failure in Canada, 2004 to 2013","author":"Canadian Institute for Health Information","year":"2015"},{"key":"bibr6-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.120833"},{"key":"bibr7-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.101863"},{"issue":"4","key":"bibr8-20543581231172407","volume":"51","author":"Whaley-Connell AT","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"bibr9-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.10.013"},{"key":"bibr10-20543581231172407","volume":"99","author":"Kidney Disease: Improving Global Outcomes Blood Pressure Work Group","year":"2021","journal-title":"Kidney Int"},{"key":"bibr11-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154900.76284.F6"},{"key":"bibr12-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1177\/003591577707001112"},{"key":"bibr13-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10237"},{"key":"bibr14-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.05.064"},{"key":"bibr15-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003423"},{"key":"bibr16-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002112"},{"key":"bibr17-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002943"},{"key":"bibr18-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.8.1027"},{"key":"bibr19-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.176313"},{"key":"bibr20-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw632"},{"key":"bibr21-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0000000000000319"},{"key":"bibr22-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.089078"},{"key":"bibr23-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.070"},{"key":"bibr24-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq024"},{"key":"bibr25-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06066"},{"key":"bibr26-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13838"},{"key":"bibr27-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.03.031"},{"key":"bibr28-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16163"},{"key":"bibr29-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000633"},{"key":"bibr30-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpw118"},{"key":"bibr31-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpw039"},{"key":"bibr32-20543581231172407","doi-asserted-by":"publisher","DOI":"10.2174\/138161209787354186"},{"key":"bibr33-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.785915"},{"key":"bibr34-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000125448.28861.fc"},{"key":"bibr35-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059669"},{"key":"bibr36-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000978"},{"key":"bibr37-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02001"},{"key":"bibr38-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpx178"},{"key":"bibr39-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.06.029"},{"key":"bibr40-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18773"},{"key":"bibr41-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2017.08.010"},{"key":"bibr42-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3366-8"},{"issue":"6","key":"bibr43-20543581231172407","volume":"71","author":"Whelton PK","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"bibr44-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.03.003"},{"key":"bibr45-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18434"},{"key":"bibr46-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.02.086"},{"key":"bibr47-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.06.039"},{"key":"bibr48-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.05.014"},{"key":"bibr49-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.07.012"},{"key":"bibr50-20543581231172407","doi-asserted-by":"publisher","DOI":"10.5414\/CN108020"},{"key":"bibr51-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000086"},{"key":"bibr52-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2012.114"},{"key":"bibr53-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2021.3079578"},{"key":"bibr54-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/hy0202.098325"},{"key":"bibr55-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.176594"},{"key":"bibr56-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04587"},{"key":"bibr57-20543581231172407","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08620817"},{"key":"bibr58-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14916"},{"key":"bibr59-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002237"},{"key":"bibr60-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.04.020"},{"key":"bibr61-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.01.007"},{"key":"bibr62-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017020148"},{"key":"bibr63-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn383"},{"key":"bibr64-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-14-88"},{"key":"bibr65-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"bibr66-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2018.02.022"},{"key":"bibr67-20543581231172407","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000982019"},{"key":"bibr68-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030848"},{"key":"bibr69-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hps021"},{"issue":"2","key":"bibr70-20543581231172407","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/MBP.0000000000000307","volume":"23","author":"Kollias A","year":"2018","journal-title":"Blood Press Monit"},{"key":"bibr71-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.194456"},{"key":"bibr72-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.05.007"},{"key":"bibr73-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm470"},{"key":"bibr74-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.12853"},{"key":"bibr75-20543581231172407","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology. ATC classification index with DDDs. https:\/\/www.whocc.no\/atc_ddd_index\/. Published 2013. Accessed April 21, 2023."},{"key":"bibr76-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179733"},{"key":"bibr77-20543581231172407","unstructured":"RAND Corporation. Kidney Disease Quality of Life Instrument (KDQOL). Date unknown. https:\/\/www.rand.org\/health-care\/surveys_tools\/kdqol.html. Accessed April 21, 2023."},{"key":"bibr78-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.07.013"},{"key":"bibr79-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1927.10502953"},{"key":"bibr80-20543581231172407","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.7.987"}],"container-title":["Canadian Journal of Kidney Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20543581231172407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20543581231172407","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20543581231172407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:21:25Z","timestamp":1777389685000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20543581231172407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":80,"alternative-id":["10.1177\/20543581231172407"],"URL":"https:\/\/doi.org\/10.1177\/20543581231172407","relation":{},"ISSN":["2054-3581","2054-3581"],"issn-type":[{"value":"2054-3581","type":"print"},{"value":"2054-3581","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"20543581231172407"}}