{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:58:30Z","timestamp":1777503510196,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Kidney Health Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    Brentuximab vedotin is a combination monoclonal antibody to anti-CD30 conjugated to the anti-tubulin agent monomethyl auristatin E. It is approved for the treatment of mycosis fungoides, Hodgkin\u2019s lymphoma, and systemic anaplastic large cell lymphoma. Brentuximab has been associated with a number of potential adverse reactions; however, reports of renal complications are rare. A 73-year-old male with mycosis fungoides was admitted to hospital with acute kidney injury following his third cycle of brentuximab. The patient\u2019s serum creatinine (SCr) was 122 \u00b5mol\/L with an estimated glomerular filtration rate (eGFR) of 58 mL\/min\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    at baseline. Following brentuximab, his SCr peaked at 1073 \u00b5mol\/L over a 4-week period. Acute interstitial nephritis (AIN) was diagnosed after other causes of acute kidney injury were ruled out and subsequently confirmed on kidney biopsy. The patient was started on prednisone 50 mg daily. This was continued for 3 weeks, followed by a 5-week taper. The patient\u2019s SCr decreased to 156 \u00b5mol\/L by completion of the prednisone taper. He was not rechallenged with brentuximab. A kidney biopsy confirmed AIN in keeping with injury from an immune checkpoint inhibitor (ICI). However, brentuximab is not an ICI. The AIN from ICIs typically has tubulointerstitial inflammatory infiltrate comprised of T lymphocytes such as the case presented here. Therefore, this represents both a novel histopathologic finding in AIN from a non-ICI medication and a rare complication of brentuximab, previously only presented in abstract form.\n                  <\/jats:p>","DOI":"10.1177\/20543581241300766","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T06:54:08Z","timestamp":1732517648000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Brentuximab-Induced Acute Interstitial Nephritis: A Case Report"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8101-9218","authenticated-orcid":false,"given":"Matthew","family":"Patterson","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Saskatchewan, Saskatoon, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pouneh","family":"Dokouhaki","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, University of Saskatchewan, Saskatoon, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chance S.","family":"Dumaine","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Saskatchewan, Saskatoon, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"MacKay","sequence":"additional","affiliation":[{"name":"Division of Hematologic Oncology, Department of Medicine, University of Saskatchewan, Saskatoon, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davina J.","family":"Tai","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Saskatchewan, Saskatoon, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"bibr1-20543581241300766","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.89"},{"key":"bibr2-20543581241300766","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.71"},{"key":"bibr3-20543581241300766","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.3969"},{"key":"bibr4-20543581241300766","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32984-2"},{"key":"bibr5-20543581241300766","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2020.1718103"},{"key":"bibr6-20543581241300766","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0160-6"},{"key":"bibr7-20543581241300766","author":"Patel I","journal-title":"J Am Soc Nephrol"},{"key":"bibr8-20543581241300766","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.20223311S180a"},{"key":"bibr9-20543581241300766","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.04.008"},{"key":"bibr10-20543581241300766","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.157.8.3635"}],"container-title":["Canadian Journal of Kidney Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20543581241300766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20543581241300766","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20543581241300766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:21:47Z","timestamp":1777389707000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20543581241300766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":10,"alternative-id":["10.1177\/20543581241300766"],"URL":"https:\/\/doi.org\/10.1177\/20543581241300766","relation":{},"ISSN":["2054-3581","2054-3581"],"issn-type":[{"value":"2054-3581","type":"print"},{"value":"2054-3581","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"20543581241300766"}}