{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:59:55Z","timestamp":1780732795167,"version":"3.54.1"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The CSN clinical practice guideline committee"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Kidney Health Dis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose of review<\/jats:title>\n                    <jats:p>1) Provide a Canadian perspective on the 2025 Kidney Disease Improving Global Outcomes (KDIGO) Autosomal Dominant Polycystic Kidney Disease (ADPKD) guidelines; 2) identify challenges and nuances in applying these guidelines in Canada; 3) highlight shifts in expert practice points for Canadian care providers; 4) outline opportunities for research, knowledge translation, and quality improvement in Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Sources of information<\/jats:title>\n                    <jats:p>The KDIGO 2025 Clinical Practice Guideline Update for the management of ADPKD, as well as a survey and discussion by Canadian experts in ADPKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The co-chairs invited stakeholders from the Canadian ADPKD community to ensure national representation, including adult and pediatric clinicians, trainees, a genetic counselor, and a patient partner with an Indigenous perspective. Members were surveyed to identify key practice points. Subgroups reviewed issues and drafted discussion topics. All members reviewed the final draft.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Findings<\/jats:title>\n                    <jats:p>The committee commented on recommendations with nuance for Canadian practitioners, especially on multidisciplinary care, challenges with genetic testing, and the use of CKD therapies like sodium-glucose transport protein 2 (SGLT2) inhibitors in ADPKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>The committee relied on the evidence summaries produced by KDIGO and the experience and knowledge of committee members. The committee did not replicate or update the systematic reviews.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20543581261455635","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:48:47Z","timestamp":1780505327000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Canadian Society of Nephrology Commentary on the 2025 Kidney Disease Improving Global Outcomes Clinical Practice Guidelines for Autosomal Dominant Polycystic Kidney Disease"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5750-6286","authenticated-orcid":false,"given":"Matthew B.","family":"Lanktree","sequence":"first","affiliation":[{"name":"McMaster University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Ashawasega","sequence":"additional","affiliation":[{"name":"Patient Partner"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheli","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G","family":"Bichet","sequence":"additional","affiliation":[{"name":"University of Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Boll\u00e9e","sequence":"additional","affiliation":[{"name":"University of Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0283-4530","authenticated-orcid":false,"given":"Pierre-Antoine","family":"Brown","sequence":"additional","affiliation":[{"name":"University of Ottawa & the Ottawa Hospital Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Girard","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine"},{"name":"University of Calgary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Goodyer","sequence":"additional","affiliation":[{"name":"McGill University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Hingwala","sequence":"additional","affiliation":[{"name":"University of Manitoba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7593-6418","authenticated-orcid":false,"given":"Mathieu","family":"Lemaire","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2935-9618","authenticated-orcid":false,"given":"Philip","family":"McFarlane","sequence":"additional","affiliation":[{"name":"Nephrology Division, St Michael\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3875-9197","authenticated-orcid":false,"given":"Louise","family":"Moist","sequence":"additional","affiliation":[{"name":"Western University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"York","family":"Pei","sequence":"additional","affiliation":[{"name":"University Health Network"},{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Normand","family":"Proulx","sequence":"additional","affiliation":[{"name":"Centre Int\u00e9gr\u00e9 de Sant\u00e9 et de Services Sociaux de L\u2019Outaouais"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Schott","sequence":"additional","affiliation":[{"name":"University of Western Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-1702","authenticated-orcid":false,"given":"Steven","family":"Soroka","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlyn","family":"Vlasschaert","sequence":"additional","affiliation":[{"name":"Queen\u2019s University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Watkins","sequence":"additional","affiliation":[{"name":"University Health Network"},{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan","family":"Alam","sequence":"additional","affiliation":[{"name":"McGill University Health Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"issue":"2","key":"e_1_3_5_2_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2024.07.009","article-title":"KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD)","volume":"107","author":"Kidney Disease: Improving Global Outcomes (KDIGO) ADPKD Work Group","year":"2025","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) ADPKD Work Group. 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