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The course of a disease is influenced not only by medical treatment but also by close relatives, friends, and especially partners, who themselves are affected by illness-related restrictions or care-giver burden. However, to date, the social context is not been adequately considered, with the social component of the biopsychosocial model often receiving only limited attention. With the We-Disease Model (WDM), we promote a systemic\/interpersonal view of mental disorders and somatic illnesses with a particular focus on the couple relationship and joint coping efforts. To address processes over time, we propose the Trajectory Model of We-Disease (TMWD) to consider the factors that influence we-disease processes and propose various trajectories over time. 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