{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:33:57Z","timestamp":1777858437871,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery Open Reports"],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>\n                      A 15-year-old neutered female domestic shorthair cat presented with lethargy and acute-onset dyspnoea. Thoracic computed tomography (CT) revealed a large, cranial mediastinal mass with an estimated volume of 180.7 cm\n                      <jats:sup>3<\/jats:sup>\n                      . Chemotherapy consisting of dexamethasone followed by L-asparaginase, prednisolone, vincristine and doxorubicin was commenced owing to the severity of disease and initial possibility of lymphoma. A diagnosis of lymphocyte-rich thymoma was made based upon histological examination, positive pancytokeratin staining, variable lymphocyte CD3 expression and T cell receptor gamma polyclonality. Thoracic CT performed 35 days after the commencement of chemotherapy showed a marked reduction in the size of the mass, with an estimated volume of 9.4 cm\n                      <jats:sup>3<\/jats:sup>\n                      . A median sternotomy and thymectomy were performed. No clinical signs have recurred 34 months after surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and relevance<\/jats:title>\n                    <jats:p>The response to chemotherapy in this case was unusual, and is likely associated with the high non-neoplastic lymphoid component of the mass. The case demonstrates that preoperative chemotherapy can be used to reduce thymoma volume prior to surgery, potentially decreasing anaesthetic risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2055116915585024","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T11:01:15Z","timestamp":1433242875000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat"],"prefix":"10.1177","volume":"1","author":[{"given":"Linda J","family":"Tong","sequence":"first","affiliation":[{"name":"Murdoch University Veterinary Hospital Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle","family":"Hosgood","sequence":"additional","affiliation":[{"name":"Murdoch University Veterinary Hospital Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Labruy\u00e8re","sequence":"additional","affiliation":[{"name":"Vet CT, St John\u2019s Innovation Centre, Cambridge, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L","family":"Bennett","sequence":"additional","affiliation":[{"name":"Murdoch University Veterinary Hospital Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"FitzGerald","sequence":"additional","affiliation":[{"name":"Murdoch University Veterinary Hospital Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E","family":"Shiel","sequence":"additional","affiliation":[{"name":"Murdoch University Veterinary Hospital Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"bibr1-2055116915585024","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2009.03.005"},{"key":"bibr2-2055116915585024","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2005.02.014"},{"key":"bibr3-2055116915585024","first-page":"679","volume-title":"Withrow & MacEwen\u2019s small animal clinical oncology","author":"de Mello Souza CH","year":"2013","edition":"5"},{"key":"bibr4-2055116915585024","doi-asserted-by":"publisher","DOI":"10.1002\/9780470376928.ch3"},{"key":"bibr5-2055116915585024","first-page":"107","volume-title":"Pathology of domestic animals","author":"Valli VE","year":"2007","edition":"5"},{"key":"bibr6-2055116915585024","volume-title":"Withrow and MacEwen\u2019s small animal clinical oncology","author":"Withrow SJ","year":"2007","edition":"4"},{"key":"bibr7-2055116915585024","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.8.1186"},{"key":"bibr8-2055116915585024","first-page":"497","volume":"30","author":"Rae CA","year":"1989","journal-title":"Can Vet J"},{"key":"bibr9-2055116915585024","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb00716.x"},{"key":"bibr10-2055116915585024","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810379435"},{"key":"bibr11-2055116915585024","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1476-5810.2004.0053a.x","volume":"2","author":"Veterinary Co-operative Oncology Group (VCOG)","year":"2004","journal-title":"Vet Comp Oncol"},{"key":"bibr12-2055116915585024","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.8.1186"},{"key":"bibr13-2055116915585024","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199111000-00024"},{"key":"bibr14-2055116915585024","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00350-6"},{"key":"bibr15-2055116915585024","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-37-5-489"},{"key":"bibr16-2055116915585024","unstructured":"North SM, Banks TA. 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