{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:29:41Z","timestamp":1777858181407,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery Open Reports"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Case summary A 6-year-old, neutered female British Shorthair cat presented with acute-onset weakness and mental dullness. Initially the cat was mildly hyperglycaemic (9.9 mmol\/l; reference interval [RI] 3.3\u20136.7 mmol\/l). Over the following 12 h the cat developed central blindness, tremors, intermittent seizures and opisthotonus. Repeat blood sampling revealed a marked hypoglycaemia (0.8 mmol\/l). Insulin level (performed on a serum sample collected while the cat was hypoglycaemic) was inappropriately elevated (1575 mIU\/l; RI 10\u201380 mIU\/l). An abdominal ultrasound was unremarkable. An exploratory laparotomy revealed a firm and erythematous left limb of the pancreas. Following surgical resection of the left limb of the pancreas, the cat returned to a euglycaemic state after a brief rebound hyperglycaemia. Histopathology revealed pancreatic fibrosis with marked multifocal micronodular hyperplasia of exocrine and endocrine cells. Synaptophysin immunohistochemistry confirmed nodular \u03b2-cell hyperplasia.<\/jats:p>\n                  <jats:p>Relevance and novel information Nesidioblastosis describes a syndrome of acquired hyperinsulinaemia and associated hypoglycaemia secondary to focal or diffuse (non-neoplastic) \u03b2-cell hyperplasia within the pancreas. Acquired nesidioblastosis has been reported in humans, where \u03b2-cell dysregulation is thought to occur in response to pancreatic injury. This is the first reported case of clinically significant hypoglycaemia due to acquired nesidioblastosis in an adult domestic cat. While this condition is rare, nesidioblastosis is being increasingly recognised in humans and it is an important differential diagnosis to consider when investigating hypoglycaemia as it cannot be distinguished from insulinoma without histopathological evaluation. While recurrence has been occasionally reported in humans, the prognosis is considered good.<\/jats:p>","DOI":"10.1177\/2055116916657846","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T21:33:32Z","timestamp":1467927212000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Hyperinsulinaemic, hypoglycaemic syndrome due to acquired nesidioblastosis in a cat"],"prefix":"10.1177","volume":"2","author":[{"given":"Lydia E","family":"Hambrook","sequence":"first","affiliation":[{"name":"Small Animal Medicine Department, Advanced Vetcare, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda A","family":"Ciavarella","sequence":"additional","affiliation":[{"name":"Small Animal Medicine Department, Advanced Vetcare, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith S","family":"Nimmo","sequence":"additional","affiliation":[{"name":"Australian Specialised Animal Pathology Laboratory, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Wayne","sequence":"additional","affiliation":[{"name":"Australian Specialised Animal Pathology Laboratory, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"bibr1-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000151617.14598.ae"},{"key":"bibr2-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7598-7"},{"key":"bibr3-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.09.010"},{"key":"bibr4-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.003"},{"key":"bibr5-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1177\/030098588902600107"},{"key":"bibr6-2055116916657846","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1993.203.11.1556"},{"key":"bibr7-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1177\/1040638712461787"},{"key":"bibr8-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0633-7"},{"key":"bibr9-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2404"},{"key":"bibr10-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2007.00404.x"},{"key":"bibr11-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1623719"},{"key":"bibr12-2055116916657846","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2460\/javma.1982.181.01.54","volume":"181","author":"Kruth SA","year":"1982","journal-title":"J Am Vet Med Assoc"},{"key":"bibr13-2055116916657846","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2460\/javma.1986.188.01.60","volume":"188","author":"Leifer CE","year":"1986","journal-title":"J Am Vet Med Assoc"},{"key":"bibr14-2055116916657846","first-page":"577","volume":"24","author":"Caywood DD","year":"1988","journal-title":"J Am Anim Hosp Assoc"},{"key":"bibr15-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.02.011"},{"key":"bibr16-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1293\/tox.25.103"},{"key":"bibr17-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1177\/030098589703400212"},{"key":"bibr18-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12381"},{"key":"bibr19-2055116916657846","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000407"}],"container-title":["Journal of Feline Medicine and Surgery Open Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2055116916657846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2055116916657846","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2055116916657846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:09:05Z","timestamp":1777507745000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2055116916657846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1177\/2055116916657846"],"URL":"https:\/\/doi.org\/10.1177\/2055116916657846","relation":{},"ISSN":["2055-1169","2055-1169"],"issn-type":[{"value":"2055-1169","type":"print"},{"value":"2055-1169","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]},"article-number":"2055116916657846"}}