{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:29:57Z","timestamp":1777858197228,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery Open Reports"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>An 8-year-old male neutered Persian cat was presented with polyuria, polydipsia, polyphagia and muscle weakness associated with a 7 month history of diabetes mellitus (DM). The cat had initially been treated with neutral protamine Hagedorn (NPH) insulin 2 U q12h, followed by porcine lente insulin 2 U q12h and, most recently, 3 U glargine insulin q12h, without improvement of clinical signs. The cat also suffered from concurrent symmetrical bilateral alopecia of thorax and forelimbs, abdominal distension and lethargy. Hyperadrenocorticism (HAC), specifically pituitary-dependent HAC, was suspected and confirmed through abdominal ultrasonography demonstrating bilateral adrenal enlargement, and a low-dose dexamethasone suppression test using 0.1 mg\/kg dexamethasone intravenously. Trilostane treatment (initially 10 mg\/cat PO q24h then increased to 10 mg\/cat PO q12h) was started and insulin sensitivity gradually improved, ultimately leading to diabetic remission after an increased in trilostane dose to 13mg\/cat PO q12h, 14 months after the DM diagnosis and 7 months after the initiation of trilostane therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance and novel information<\/jats:title>\n                    <jats:p>DM in cats with HAC is a difficult combination of diseases to treat. To our knowledge this is the first reported case of diabetic remission in a feline patient with HAC as a result of treatment with trilostane. Further work should focus on whether fine-tuning of trilostane-treatment protocols in cats with concurrent DM and HAC could lead to a higher proportion of diabetic remissions in this patient group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2055116918767708","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T02:24:35Z","timestamp":1523931875000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Diabetes mellitus remission in a cat with pituitary-dependent hyperadrenocorticism after trilostane treatment"],"prefix":"10.1177","volume":"4","author":[{"given":"Adriana Cunha","family":"Muschner","sequence":"first","affiliation":[{"name":"Department of Animal Medicine, Faculty of Veterinary Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Venzon","family":"Varela","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine, Faculty of Veterinary Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Hazuchova","sequence":"additional","affiliation":[{"name":"Diabetic Remission Clinic, Department of Clinical Science and Services, Royal Veterinary College, University of London, North Mimms, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stijn JM","family":"Niessen","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine, Faculty of Veterinary Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lan Gomes","family":"P\u00f6ppl","sequence":"additional","affiliation":[{"name":"Diabetic Remission Clinic, Department of Clinical Science and Services, Royal Veterinary College, University of London, North Mimms, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"bibr1-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12178"},{"key":"bibr2-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12298"},{"key":"bibr3-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2011.12.001"},{"key":"bibr4-2055116918767708","doi-asserted-by":"publisher","DOI":"10.22233\/9781905319893.17"},{"key":"bibr5-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1002\/9781118997093.ch7"},{"key":"bibr6-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2007.02.004"},{"key":"bibr7-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2012.12.004"},{"key":"bibr8-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2009.10.007"},{"key":"bibr9-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14357"},{"key":"bibr10-2055116918767708","doi-asserted-by":"publisher","DOI":"10.22233\/9781905319893.13"},{"key":"bibr11-2055116918767708","doi-asserted-by":"crossref","unstructured":"Rand J. Feline diabetes mellitus. In: Rand J, Behrend EN, Gunn-Moore D, et al (eds). Clinical endocrinology of companion animals. Chichester: Wiley-Blackwell, 2013, pp 169\u2013190.","DOI":"10.1002\/9781118997093.ch16"},{"key":"bibr12-2055116918767708","volume":"44","author":"P\u00f6ppl AG","year":"2016","journal-title":"Acta Sci Vet"},{"key":"bibr13-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15571880"},{"key":"bibr14-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2004.09.002"},{"key":"bibr15-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127794"},{"key":"bibr16-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0201.x"},{"key":"bibr17-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12608"},{"key":"bibr18-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14662"},{"key":"bibr19-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.08.014"},{"key":"bibr20-2055116918767708","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.05.016"}],"container-title":["Journal of Feline Medicine and Surgery Open Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2055116918767708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2055116918767708","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2055116918767708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:09:24Z","timestamp":1777507764000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2055116918767708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1177\/2055116918767708"],"URL":"https:\/\/doi.org\/10.1177\/2055116918767708","relation":{},"ISSN":["2055-1169","2055-1169"],"issn-type":[{"value":"2055-1169","type":"print"},{"value":"2055-1169","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"article-number":"2055116918767708"}}