{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:30:13Z","timestamp":1777858213183,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery Open Reports"],"published-print":{"date-parts":[[2019,1]]},"abstract":"\n Case summary<\/jats:title>\n \n A 3-year-7-month-old female neutered domestic shorthair cat was presented for further investigation of acute-onset neurological abnormalities, including marked decreased mentation, ataxia and abnormal cranial nerve responses, with concurrent marked pyrexia (40\u00baC). Initial blood testing was non-specific with mild-to-moderate increases in alanine aminotransferase (ALT) (194 IU\/l; reference interval [RI] 17\u201362 IU\/l), aspartate aminotransferase (AST; 150 IU\/l [RI 0\u201351 IU\/l]) and total bilirubin (20 \u00b5mol\/l; RI 0\u201311 \u00b5mol\/l), and neutropenia (1.17 \u00d710\n 9<\/jats:sup>\n \/l; RI 2.5\u201312.5 \u00d710\n 9<\/jats:sup>\n \/l). Brain MRI and cerebrospinal fluid analysis were unremarkable and Toxoplasma serology was negative. Worsening of hepatic biochemical parameters (ALT 265 IU\/l, AST 205 IU\/l, total bilirubin 42.9 \u00b5mol\/l) led to further investigations for liver disease, including ultrasound, fine-needle aspirate cytology, histology, fluorescent in situ hybridisation and culture of liver tissue and bile, resulting in a diagnosis of Yersinia pseudotuberculosis hepatitis. The cat was treated with a combination of potentiated amoxicillin (62.5 mg PO q12h), marbofloxacin (5mg PO q24h) and combined s-adenosyl methionine (SAMe)\/silybin (90 mg PO q24h), and made a full recovery. Follow-up over 14 months identified a persistent mild increase in ALT, despite no apparent ongoing disease.\n <\/jats:p>\n <\/jats:sec>\n \n Relevance and novel information<\/jats:title>\n Yersinia pseudotuberculosis hepatitis should be considered as a differential diagnosis in cats presenting with acute-onset neurological signs, and, when diagnosed, can be successfully treated with a combination of marbofloxacin, potentiated amoxicillin and SAMe\/silybin. This is the first such case treated successfully with licensed veterinary antimicrobials and the first instance where Y pseudotuberculosis hepatitis has presented with primarily neurological clinical signs.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/2055116919853644","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T23:52:03Z","timestamp":1559260323000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Successful treatment of\n Yersinia pseudotuberculosis<\/i>\n hepatitis in a cat presenting with neurological abnormalities"],"prefix":"10.1177","volume":"5","author":[{"given":"Dan","family":"Thompson","sequence":"first","affiliation":[{"name":"Queen\u2019s Veterinary School Hospital, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"bibr1-2055116919853644","unstructured":"Hirsh DC. Enterobacteriaceae:\n Yersinia\n . In: Hirsh DC, Maclachlan NJ, Walker RL (eds). Veterinary microbiology. 2nd ed. Oxford: Blackwell Publishing, 2004, pp 77\u201379."},{"key":"bibr2-2055116919853644","doi-asserted-by":"publisher","DOI":"10.1136\/vr.129.5.103"},{"key":"bibr3-2055116919853644","unstructured":"Greene CE. Yersiniosis. In Green CE (ed). Infectious diseases of the dog and cat. 4th ed. St Louis, MO: Elsevier Saunders, 2012, p 390."},{"key":"bibr4-2055116919853644","first-page":"461","volume":"81","author":"Mair NS","year":"1967","journal-title":"Vet Rec"},{"key":"bibr5-2055116919853644","first-page":"361","volume":"20","author":"Spearman JG","year":"1979","journal-title":"Can Vet J"},{"key":"bibr6-2055116919853644","doi-asserted-by":"publisher","DOI":"10.1136\/vr.100.20.424"},{"key":"bibr7-2055116919853644","first-page":"91","volume":"174","author":"Allard AW","year":"1979","journal-title":"J Am Vet Med Assoc"},{"key":"bibr8-2055116919853644","doi-asserted-by":"publisher","DOI":"10.1136\/vr.91.27.676"}],"container-title":["Journal of Feline Medicine and Surgery Open Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2055116919853644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2055116919853644","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2055116919853644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:09:48Z","timestamp":1777507788000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2055116919853644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1177\/2055116919853644"],"URL":"https:\/\/doi.org\/10.1177\/2055116919853644","relation":{},"ISSN":["2055-1169","2055-1169"],"issn-type":[{"value":"2055-1169","type":"print"},{"value":"2055-1169","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"2055116919853644"}}