{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:21:59Z","timestamp":1784071319588,"version":"3.55.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100011179","name":"Cornell Feline Health Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery Open Reports"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>This report describes a cat with chronic, progressive, non-painful, non-lateralizing multifocal neurologic clinical signs associated with feline infectious peritonitis (FIP). The cat initially presented as underweight, despite a good appetite, and a complete blood count showed non-regenerative anemia. Three months later the cat was returned having developed ataxia and paraparesis, which then progressed over 2 months to tetraparesis, tail plegia, urinary and fecal incontinence, and titubation. Histologic examination of the tissues with subsequent immunohistochemistry confirmed FIP-associated meningoencephalomyelitis following necropsy. Molecular analysis of the coronavirus spike protein within the tissues identified a specific, functionally relevant amino acid change (R793M), which was only identified in tissues associated with the central nervous system (ie, brain and spinal cord).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance and novel information<\/jats:title>\n                    <jats:p>This case report describes an early presentation of a cat with primarily neurologic FIP, with molecular characterization of the virus within various tissues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2055116919856103","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T07:44:20Z","timestamp":1561535060000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Distinct mutation in the feline coronavirus spike protein cleavage activation site in a cat with feline infectious peritonitis-associated meningoencephalomyelitis"],"prefix":"10.1177","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3703-5026","authenticated-orcid":false,"given":"Nicole M","family":"Andr\u00e9","sequence":"first","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brieuc","family":"Cossic","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Section of Anatomic Pathology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Section of Anatomic Pathology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary R","family":"Whittaker","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"bibr1-2055116919856103","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.04.016"},{"key":"bibr2-2055116919856103","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.04.017"},{"key":"bibr3-2055116919856103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.09.004"},{"key":"bibr4-2055116919856103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb02632.x"},{"key":"bibr5-2055116919856103","unstructured":"MacLaughlan NJ, Dubovi EJ. 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