{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:30:26Z","timestamp":1777858226069,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery Open Reports"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>An 11-year-old female, reportedly spayed, domestic shorthair cat was examined for a 4-month history of weight loss, aggression, urine spraying, malodorous urine and estrus-like behavior. Physical examination revealed thickened skin, a mildly prominent vulva and confirmed malodorous urine. On abdominal ultrasonography, a 6 mm hypoechoic nodule was found in the left cranial abdomen. An adrenocorticotropic hormone (ACTH) stimulation test with adrenal panel revealed elevated serum concentrations of androstenedione and testosterone pre- and post-cosyntropin stimulation, mildly decreased cortisol pre- and post-cosyntropin stimulation, and decreased resting aldosterone. Exploratory laparotomy was performed and a cystic, nodular mass was found in the region of the left ovary. The mass was surgically removed and submitted for histopathology; results were conclusive for an ovarian remnant with an intact corpus luteum and non-neoplastic parovarian cysts. Previously observed clinical signs resolved within two weeks of ovariectomy. A follow-up ACTH stimulation test with adrenal panel 6 weeks postoperatively revealed normalization of serum androstenedione, testosterone and cortisol concentrations. Four years postoperatively, at the time of writing, the cat remains free of clinical signs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance and novel information<\/jats:title>\n                    <jats:p>We are unaware of any previously reported cases of non-neoplastic ovarian remnants associated with clinically relevant hyperandrogenism. A non-neoplastic ovarian-dependent hyperandrogenism should be included as a differential diagnosis of spayed female cats showing aggression and urine spraying behavior.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2055116919885698","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T04:31:11Z","timestamp":1573705871000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hyperandrogenism associated with an ovarian remnant in a spayed female cat"],"prefix":"10.1177","volume":"5","author":[{"given":"Sarah A","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott L","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, MedVet Indianapolis, Carmel, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J","family":"Birchard","sequence":"additional","affiliation":[{"name":"Department of Surgery, MedVet Toledo, Toledo, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"bibr1-2055116919885698","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-36-6-512"},{"key":"bibr2-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2004.tb00234.x"},{"key":"bibr3-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2005.tb02708.x"},{"key":"bibr4-2055116919885698","doi-asserted-by":"publisher","DOI":"10.2460\/javma.234.4.505"},{"key":"bibr5-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.02.002"},{"key":"bibr6-2055116919885698","first-page":"1077","volume":"57","author":"Nadolski AC","year":"2016","journal-title":"Can Vet J"},{"key":"bibr7-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12655"},{"key":"bibr8-2055116919885698","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-37-3-290"},{"key":"bibr9-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1177\/104063879500700432"},{"key":"bibr10-2055116919885698","doi-asserted-by":"publisher","DOI":"10.2460\/javma.236.5.548"},{"key":"bibr11-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1177\/030098588502200610"},{"key":"bibr12-2055116919885698","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-36-4-323"},{"key":"bibr13-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1371\/journal\/pone.0110683"},{"key":"bibr14-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1210\/er.2015-1104"},{"key":"bibr15-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13492"},{"key":"bibr16-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12781"},{"key":"bibr17-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100307"},{"key":"bibr18-2055116919885698","first-page":"71","volume":"189","author":"Altera KP","year":"1986","journal-title":"J Am Vet Med Assoc"},{"key":"bibr19-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1210\/er.16.3.322"},{"key":"bibr20-2055116919885698","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2017.02.045"}],"container-title":["Journal of Feline Medicine and Surgery Open Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2055116919885698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2055116919885698","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2055116919885698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:09:58Z","timestamp":1777507798000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2055116919885698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1177\/2055116919885698"],"URL":"https:\/\/doi.org\/10.1177\/2055116919885698","relation":{},"ISSN":["2055-1169","2055-1169"],"issn-type":[{"value":"2055-1169","type":"print"},{"value":"2055-1169","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]},"article-number":"2055116919885698"}}