{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:36:18Z","timestamp":1793932578947,"version":"4.8.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery Open Reports"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>This case report describes a 9-year-old neutered male cat with a functional adrenal tumor showing aggression toward other cats in the household, excessive meowing and urine spraying. The diagnosis was made based on the clinical signs, an enlarged right adrenal gland on ultrasound, penile spines and elevated sex hormones on an adrenocorticotropic hormone stimulation test. The cat was submitted to celiotomy and adrenalectomy. Histopathological examination confirmed the adrenocortical adenoma. Three months after surgery the penile spines disappeared and urine spraying, as well as excessive meowing, had greatly decreased; however, aggressive behavior took much longer to stop and required behavior therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance and novel information<\/jats:title>\n                    <jats:p>Functional adrenal tumors producing only sex hormones and behavioral changes are uncommon. The cat reported herein started showing behavioral changes before spines appeared on the penis, and structural alterations in the adrenal gland at the abdominal ultrasonography were detected. Considering all the possible implications resulting from severe behavior problems such as cat\u2013cat aggression, from a permanent separation of the cats to relinquishment, a detailed investigation of underlying medical mechanisms in these animals is crucial from the start. Examinations may need to be repeated later in the course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2055116920981247","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T21:10:06Z","timestamp":1610658606000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A case of behavioral changes in a castrated male cat due to a functional adrenocortical adenoma producing testosterone and androstenedione"],"prefix":"10.1177","volume":"7","author":[{"given":"Archivaldo","family":"Reche Junior","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Vetmasters and 4 Cats Hospital, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2564-9055","authenticated-orcid":false,"given":"Daniela","family":"Ramos","sequence":"additional","affiliation":[{"name":"Psicovet, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3003-2970","authenticated-orcid":false,"given":"Mariana","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Vetmasters and 4 Cats Hospital, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Artur GP","family":"da Silva","sequence":"additional","affiliation":[{"name":"Tatuapet Veterinary Clinic, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Hirai","sequence":"additional","affiliation":[{"name":"Vetmasters and 4 Cats Hospital, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro V","family":"Horta","sequence":"additional","affiliation":[{"name":"Vetmasters and 4 Cats Hospital, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"bibr1-2055116920981247","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(97)50035-0"},{"key":"bibr2-2055116920981247","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.2002.0178"},{"key":"bibr3-2055116920981247","first-page":"592","volume-title":"The cat: clinical medicine and management.","author":"Peterson 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