{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:16:07Z","timestamp":1788470167348,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery Open Reports"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A 9-month-old intact female domestic mediumhair cat presented with a 5-month history of obtundation, lethargy, hypernatremia (181\u2009mmol\/l; reference interval [RI] 151\u2013158\u2009mmol\/l), hyperchloremia (142\u2009mmol\/l; RI 117\u2013126\u2009mmol\/l), azotemia (blood urea nitrogen 51\u2009mg\/dl; RI 18\u201333\u2009mg\/dl), creatinine 3.0\u2009mg\/dl (RI 1.1\u20132.2\u2009mg\/dl), hyperphosphatemia (8.3\u2009mg\/dl; RI 3.2\u20136.3\u2009mg\/dl) and total hypercalcemia (11.4\u2009mg\/dl; RI 9\u201310.9\u2009mg\/dl), with concurrent polyuria with adipsia. Neurologic evaluation revealed proprioceptive deficits, and this finding paired with a history of focal seizure-like activity despite improving sodium concentrations suggested a cerebrothalamic lesion. For this reason, and historical and biochemical findings consistent with adipsic diabetes insipidus (DI), MRI of the brain was performed, which revealed a lesion of the hypophyseal fossa consistent with a pituitary cyst. Given the patient\u2019s age and the timeline of clinical signs, a congenital pituitary cyst was strongly suspected. The patient was managed initially with intravenous fluids to correct the hypernatremia, then managed for more than 4 years with topical ocular desmopressin acetate administration and free water administered through a feeding tube. This cat\u2019s clinical diagnosis included a congenital pituitary cyst with subsequent central DI and primary adipsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Relevance and novel information<\/jats:title>\n                    <jats:p>The clinical presentations of primary adipsia or central DI are both rare in cats. This is the first report to describe these conditions occurring in a cat owing to a congenital pituitary cyst and describes successful long-term management of this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2055116921990294","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T05:50:22Z","timestamp":1614405022000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Congenital pituitary cyst resulting in adipsic central diabetes insipidus and secondary hypernatremia in a cat"],"prefix":"10.1177","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2953-376X","authenticated-orcid":false,"given":"Janny","family":"Evenhuis","sequence":"first","affiliation":[{"name":"William R Pritchard Veterinary Medical Teaching Hospital, University of California Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Della-Maggiore","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA"},{"name":"MarQueen Pet Emergency and Specialty Group, Roseville, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystle L","family":"Reagan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,27]]},"reference":[{"key":"bibr1-2055116921990294","first-page":"1","volume-title":"Canine and feline endocrinology","author":"Nelson RW","year":"2014","edition":"4"},{"key":"bibr2-2055116921990294","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1983.tb00402.x"},{"key":"bibr3-2055116921990294","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2004.tb00256.x"},{"key":"bibr4-2055116921990294","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.07.005"},{"key":"bibr5-2055116921990294","first-page":"545","volume":"170","author":"Rogers W","year":"1977","journal-title":"J Am Vet Med Assoc"},{"key":"bibr6-2055116921990294","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2005.03.008"},{"key":"bibr7-2055116921990294","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1983.tb05975.x"},{"key":"bibr8-2055116921990294","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1982.tb01663.x"},{"key":"bibr9-2055116921990294","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-002-0985-0"},{"key":"bibr10-2055116921990294","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12398"},{"key":"bibr11-2055116921990294","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20412"},{"key":"bibr12-2055116921990294","doi-asserted-by":"publisher","DOI":"10.1177\/0300985818784162"},{"key":"bibr13-2055116921990294","unstructured":"Feldman EC, Nelson RW, Reusch C, et al. 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