{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:00:28Z","timestamp":1790625628410,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DIGITAL HEALTH"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Due to the growing complexity in monitoring and treatment of many disorders, disease-specific care and research networks offer patients certified healthcare. However, the networks\u2019 ability to provide health services close to patients\u2019 homes usually remains vague. Digital Health Technologies (DHTs) help to provide better care, especially if implemented in a targeted manner in regions undersupplied by specialised networks. Therefore, we used a car travel time-based isochrone approach to identify care gaps using the example of the neuroinflammation-focused German healthcare and research networks for multiple sclerosis (MS), myasthenia gravis (MG), myositis and immune-mediated neuropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Excellence centres were mapped, and isochrones for 30, 60, 90 and 120\u2005minutes were calculated. The resulting geometric figures were aggregated and used to mask the global human settlement population grid 2019 to estimate German inhabitants that can reach centres within the given periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>While 96.48% of Germans can drive to an MS-focused centre within one hour, coverage is lower for the rare disease networks for MG (48.3%), myositis (43.1%) and immune-mediated neuropathy (56.7%). Within 120\u2005minutes, more than 80% of Germans can reach a centre of any network. Besides the generally worse covered rural regions such as North-Eastern Germany, the rare disease networks also show network-specific regional underrepresentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An isochrone-based approach helps identify regions where specialised care is hard to reach, which might be especially troublesome in the case of an often disabled patient collective. Patient care could be improved by focusing deployments of disease-specific DHTs on these areas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552076231152989","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T18:20:28Z","timestamp":1674843628000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Driving time-based identification of gaps in specialised care coverage: An example of neuroinflammatory diseases in Germany"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-1415","authenticated-orcid":false,"given":"Lars","family":"Masanneck","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical Faculty University Hospital D\u00fcsseldorf, D\u00fcsseldorf, Germany"},{"name":"Hasso Plattner Institute, University of Potsdam, Potsdam, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8901-5572","authenticated-orcid":false,"given":"Saskia","family":"R\u00e4uber","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty University Hospital D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina B","family":"Schroeter","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty University Hospital D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9007-027X","authenticated-orcid":false,"given":"Sophie","family":"Lehnerer","sequence":"additional","affiliation":[{"name":"Department of Neurology with Experimental Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"Department of Neurology with Experimental Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, NeuroCure Clinical Research Center, Berlin, Germany"},{"name":"Centre for Stroke Research Berlin, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Berlin Institute of Health at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Digital Health Center, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tjalf","family":"Ziemssen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Carl Gustav Carus, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Ruck","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty University Hospital D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven G.","family":"Meuth","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty University Hospital D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pawlitzki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty University Hospital D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"bibr1-20552076231152989","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-8-129"},{"key":"bibr2-20552076231152989","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00477-5"},{"key":"bibr3-20552076231152989","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10891-1"},{"key":"bibr4-20552076231152989","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.022"},{"key":"bibr5-20552076231152989","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02448-4"},{"key":"bibr6-20552076231152989","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab465"},{"key":"bibr7-20552076231152989","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103927"},{"key":"bibr8-20552076231152989","doi-asserted-by":"publisher","DOI":"10.1177\/2055217318814562"},{"key":"bibr9-20552076231152989","first-page":"e1","volume":"88","author":"Flachenecker 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