{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:57:18Z","timestamp":1791554238655,"version":"4.3.4"},"reference-count":59,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Province Key Research and Development Program of Zhejiang","award":["2021C03116"],"award-info":[{"award-number":["2021C03116"]}]},{"name":"Province Key Research and Development Program of Zhejiang","award":["2022C03064"],"award-info":[{"award-number":["2022C03064"]}]},{"name":"scientific research project of Zhejiang Chinese Medical University","award":["2021JKZDZC04"],"award-info":[{"award-number":["2021JKZDZC04"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DIGITAL HEALTH"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Mild cognitive impairment (MCI) due to Alzheimer's disease (AD), as an early stage of AD, is an important point for early warning of AD. Neuropathological studies have shown that AD pathology in pre-dementia patients involves the hippocampus and caudate nucleus, which are responsible for controlling cognitive mechanisms such as the spatial executive process (SEP). The aim of this study is to design a new method for early warning of MCI due to AD by dynamically evaluating SEP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We designed fingertip interaction handwriting digital evaluation paradigms and analyzed the dynamic trajectory of fingertip interaction and image data during \u201cclock drawing\u201d and \u201crepetitive writing\u201d tasks. Extracted fingertip interaction digital biomarkers were used to assess participants\u2019 SEP disorders, ultimately enabling intelligent diagnosis of MCI due to AD. A cross-sectional study demonstrated the predictive performance of this new method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We enrolled 30 normal cognitive (NC) elderly and 30 MCI due to AD patients, and clinical research results showed that there may be neurobehavioral differences between the two groups in digital biomarkers captured during SEP. The early warning performance for MCI due to AD of this new method (areas under the curve (AUC)\u2009=\u20090.880) is better than that of the Minimum Mental State Examination (MMSE) neuropsychological scale (AUC\u2009=\u20090.856) assessed by physicians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with MCI due to AD may have SEP disorders, and this new method based on dynamic evaluation of SEP will provide a novel human\u2013computer interaction and intelligent early warning method for home and community screening of MCI due to AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552076231194938","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T05:51:12Z","timestamp":1692856272000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["A new early warning method for mild cognitive impairment due to Alzheimer's disease based on dynamic evaluation of the \u201cspatial executive process\u201d"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3519-8814","authenticated-orcid":false,"given":"Kai","family":"Li","sequence":"first","affiliation":[{"name":"Zhejiang-Japan Digital Diagnosis and Treatment and Equipment of Integrated Traditional Chinese Medicine and Western Medicine for Major Brain Diseases Joint Laboratory, Zhejiang Chinese Medical University, Hangzhou, China"},{"name":"School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China"},{"name":"Joint Laboratory of Police Health Smart Surveillance, Zhejiang Police College, Hangzhou, 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Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiakang","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang-Japan Digital Diagnosis and Treatment and Equipment of Integrated Traditional Chinese Medicine and Western Medicine for Major Brain Diseases Joint Laboratory, Zhejiang Chinese Medical University, Hangzhou, China"},{"name":"School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouqiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhejiang-Japan Digital Diagnosis and Treatment and Equipment of Integrated Traditional Chinese Medicine and Western Medicine for Major Brain Diseases Joint Laboratory, Zhejiang Chinese Medical University, Hangzhou, China"},{"name":"School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang-Japan Digital Diagnosis and Treatment and Equipment of Integrated Traditional Chinese Medicine and Western Medicine for Major Brain Diseases Joint Laboratory, Zhejiang Chinese Medical University, Hangzhou, China"},{"name":"School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwu","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang-Japan Digital Diagnosis and Treatment and Equipment of Integrated Traditional Chinese Medicine and Western Medicine for Major Brain Diseases Joint Laboratory, Zhejiang Chinese Medical University, Hangzhou, China"},{"name":"School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, 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