{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:00:03Z","timestamp":1777550403172,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008723","name":"Universidad de C\u00e1diz","doi-asserted-by":"publisher","award":["PR2022-020"],"award-info":[{"award-number":["PR2022-020"]}],"id":[{"id":"10.13039\/501100008723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DIGITAL HEALTH"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyse the effectiveness of a physical exercise programme guided by a mobile health technology system (COVIDReApp) for patients with post-acute COVID-19 syndrome. This syndrome is a multisystem disease that occurs in people with a history of COVID-19 between 1 and 3 months after the onset of the disease. This study will assess the impact of the intervention on fatigue, post-exertional dyspnoea, quality of life, pain severity, physical fitness, anxiety, depression and cognitive function. We also aim to analyse whether there are associations between the variables studied and the evolution of these associations during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A single-blind randomised controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred patients diagnosed with post-acute COVID-19 will be enrolled and randomly assigned to two groups. The experimental group will perform the intervention through a physical exercise programme guided by the COVIDReApp system, whereas the control group will perform the programme in paper format. Study outcomes will be collected at baseline and at 4, 12 and 24 weeks. Student's t-tests or Mann\u2013Whitney U-tests will be used to analyse differences between groups, mixed ANOVA for differences over time and longitudinal structural equations for associations between variables at follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study is based on current evidence regarding exercise prescription recommendations for patients with post-acute COVID-19 syndrome. Our intervention is supported by a solid theoretical framework; however, challenges include tailoring the physical exercise programme to everyone's predominant symptoms and ensuring adherence to the programme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>NCT05725538.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552076241247936","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T09:47:11Z","timestamp":1730195231000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Enhancing exercise intervention for patients with post-acute COVID-19 syndrome using mobile health technology: The COVIDReApp randomised controlled trial protocol"],"prefix":"10.1177","volume":"10","author":[{"given":"Andres J","family":"Salvador-Ruiz","sequence":"first","affiliation":[{"name":"Department of Nursing and Physiotherapy, University of Cadiz, Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6465-982X","authenticated-orcid":false,"given":"Jose A","family":"Moral-Munoz","sequence":"additional","affiliation":[{"name":"Department of Nursing and Physiotherapy, University of Cadiz, Cadiz, Spain"},{"name":"Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain"},{"name":"Observatory of Pain, Gr\u00fcnenthal Foundation-University of Cadiz, Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Salazar","sequence":"additional","affiliation":[{"name":"Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain"},{"name":"Observatory of Pain, Gr\u00fcnenthal Foundation-University of Cadiz, Cadiz, Spain"},{"name":"Department of Statistics and Operational Research, University of Cadiz, Puerto Real, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lucena-Anton","sequence":"additional","affiliation":[{"name":"Department of Nursing and Physiotherapy, University of Cadiz, Cadiz, Spain"},{"name":"Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"De Sola","sequence":"additional","affiliation":[{"name":"Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain"},{"name":"Observatory of Pain, Gr\u00fcnenthal Foundation-University of Cadiz, Cadiz, Spain"},{"name":"Department of General Economics, Area of Sociology, University of Cadiz, Jerez Frontera, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Failde","sequence":"additional","affiliation":[{"name":"Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain"},{"name":"Observatory of Pain, Gr\u00fcnenthal Foundation-University of Cadiz, Cadiz, Spain"},{"name":"Preventive Medicine and Public Health Area, University of Cadiz, Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Due\u00f1as","sequence":"additional","affiliation":[{"name":"Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain"},{"name":"Observatory of Pain, Gr\u00fcnenthal Foundation-University of Cadiz, Cadiz, Spain"},{"name":"Department of Statistics and Operational Research, University of Cadiz, Puerto Real, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"bibr1-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1016\/j.rce.2021.10.003"},{"key":"bibr2-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2023.05.003"},{"key":"bibr3-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2023.04.008"},{"key":"bibr4-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2021-005427"},{"key":"bibr5-20552076241247936","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.837420"},{"key":"bibr6-20552076241247936","unstructured":"Grand View Research.\n                      mHealth market size, share & trends analysis report by component, by services (monitoring services, diagnosis services), by participants (mobile operators, devices vendors), by region, and segment forecasts, 2023\u20132030 [Internet]\n                      ; 2023. Available from: https:\/\/www.grandviewresearch.com\/industry-analysis\/mhealth-market."},{"key":"bibr7-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2019-214246"},{"key":"bibr8-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00703-9"},{"key":"bibr9-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmab076"},{"key":"bibr10-20552076241247936","doi-asserted-by":"publisher","DOI":"10.24038\/mgyf.2021.016"},{"key":"bibr11-20552076241247936","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-266574\/v1"},{"key":"bibr12-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-023-02107-z"},{"key":"bibr13-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab297"},{"key":"bibr14-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32656-8"},{"key":"bibr15-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1177\/21501319211067674"},{"key":"bibr16-20552076241247936","doi-asserted-by":"publisher","DOI":"10.12820\/rbafs.27e0270"},{"key":"bibr17-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2023.01.003"},{"key":"bibr18-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-023-00900-w"},{"key":"bibr19-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1186\/s13030-022-00250-5"},{"key":"bibr20-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1136\/bmjmilitary-2021-001856"},{"key":"bibr21-20552076241247936","first-page":"1","volume":"10","author":"Huang J","year":"2022","journal-title":"Front Public Health"},{"key":"bibr22-20552076241247936","doi-asserted-by":"publisher","DOI":"10.2196\/45711"},{"key":"bibr23-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-35058-y"},{"key":"bibr24-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7586"},{"key":"bibr25-20552076241247936","first-page":"87","author":"National Institute for Health and Care Excellence","year":"2021","journal-title":"NICE Guidelines"},{"key":"bibr26-20552076241247936","first-page":"1","author":"National Institute for Health and Care Excellence SIGN (SIGN) and RC of GP (RCGP)","year":"2022","journal-title":"Scottish Intercollegiate Guidelines Network (SIGN) and Royal College of General Practitioners (RCGP)"},{"key":"bibr27-20552076241247936","volume-title":"ACSM\u2019s guidelines for exercise testing and prescription","author":"American College of Sports Medicine","year":"2018","edition":"10"},{"key":"bibr28-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"bibr29-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1080\/10749357.2018.1550957"},{"key":"bibr30-20552076241247936","first-page":"74","volume":"54","author":"Amado Diago CA","year":"2018","journal-title":"Arch Bronconeumol [Internet]"},{"key":"bibr31-20552076241247936","first-page":"1","volume":"5","author":"Hayes CJ","year":"2017","journal-title":"Healthcare (Basel)"},{"key":"bibr32-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.4.378"},{"key":"bibr33-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1123\/japa.7.2.129"},{"key":"bibr34-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.10.006"},{"key":"bibr35-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00296-3"},{"key":"bibr36-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09447-1"},{"key":"bibr37-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1027\/1614-2241.4.1.37"},{"key":"bibr38-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.so.03.080177.001033"},{"key":"bibr39-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-18"},{"key":"bibr40-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.12.155"},{"key":"bibr41-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2022.2063843"},{"key":"bibr42-20552076241247936","volume":"123","author":"Chuang HJ","year":"2023","journal-title":"J Formos Med Assoc [Internet]"},{"key":"bibr43-20552076241247936","first-page":"66","volume":"60","author":"Centeno A","year":"2021","journal-title":"Rev Med Inst Mex Seguro Soc [Internet]"},{"key":"bibr44-20552076241247936","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00489.2022"},{"key":"bibr45-20552076241247936","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192214899"},{"key":"bibr46-20552076241247936","doi-asserted-by":"publisher","DOI":"10.3390\/v14122797"},{"key":"bibr47-20552076241247936","first-page":"47","volume":"293","author":"Ruckser-Scherb R","year":"2022","journal-title":"App. Stud Health Technol Inform"},{"key":"bibr48-20552076241247936","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40945-021-00126-x","volume":"12","author":"Lang S","year":"2022","journal-title":"Arch Physiother [Internet]"},{"key":"bibr49-20552076241247936","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19074133"}],"container-title":["DIGITAL HEALTH"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20552076241247936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20552076241247936","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20552076241247936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:50:57Z","timestamp":1777398657000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20552076241247936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":49,"alternative-id":["10.1177\/20552076241247936"],"URL":"https:\/\/doi.org\/10.1177\/20552076241247936","relation":{},"ISSN":["2055-2076","2055-2076"],"issn-type":[{"value":"2055-2076","type":"print"},{"value":"2055-2076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"20552076241247936"}}