{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:03:07Z","timestamp":1777550587535,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DIGITAL HEALTH"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Despite the worsening of the opioid epidemic, access to quality treatment for opioid use disorder (OUD) including buprenorphine remains a challenge. With the onset of the COVID-19 public health emergency, temporary regulatory changes and expanded reimbursement for telehealth services allowed for the rapid expansion of remote treatment for OUD and increased access to buprenorphine, but limited research exists to support this revolutionary shift in care delivery. This study evaluates the feasibility and acceptability of a novel digital therapeutic intervention for OUD combining buprenorphine and behavioral therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults ( n\u2009=\u200927) with OUD received treatment with daily sublingual buprenorphine and psychosocial treatment delivered digitally via a smartphone app over 12 weeks. Participants were evaluated monthly for continued opioid use, medication adherence, anxiety and depression indicators, abstinence self-efficacy, craving, and overall well-being, as well as a one-time measure of treatment acceptability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants reported increased opioid abstinence days from baseline ( M\u2009=\u20098.2, SD\u2009=\u20098.6) to 12 weeks per 30 days ( M\u2009=\u200924.9, SD\u2009=\u200910.1), t(20)\u2009=\u2009\u22126.5, p\u2009&lt;\u2009.000, with strong medication adherence across study waves (96.2%). Anxiety and depression indicators, and opioid craving significantly decreased, and abstinence self-efficacy and overall well-being significantly increased following the intervention. Participants also demonstrated high rates of treatment engagement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>As current public health emergency regulatory changes are reviewed for permanency, this feasibility and acceptability study of a novel digital therapeutic intervention for OUD including buprenorphine adds to the growing evidence that supports maintaining telehealth access for quality OUD treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552076241258400","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T03:18:34Z","timestamp":1716952714000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Feasibility and acceptability of a novel digital therapeutic combining behavioral and pharmacological treatment for opioid use disorder"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1504-4968","authenticated-orcid":false,"given":"Laura B.","family":"Monico","sequence":"first","affiliation":[{"name":"Department of Clinical Affairs, Pelago, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Eastlick","sequence":"additional","affiliation":[{"name":"Department of Clinical Affairs, Pelago, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darcy","family":"Michero","sequence":"additional","affiliation":[{"name":"Department of Clinical Affairs, Pelago, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peyton","family":"Pielsticker","sequence":"additional","affiliation":[{"name":"Department of Clinical Affairs, Pelago, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzette","family":"Glasner","sequence":"additional","affiliation":[{"name":"Department of Clinical Affairs, Pelago, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"bibr1-20552076241258400","unstructured":"Anonymous Understanding the Opioid Overdose Epidemic, https:\/\/www.cdc.gov\/opioids\/basics\/epidemic.html (2022, accessed February 21, 2023)."},{"key":"bibr2-20552076241258400","author":"Chandler RK","journal-title":"Drug Alcohol Depend"},{"key":"bibr3-20552076241258400","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-022-01346-z"},{"key":"bibr4-20552076241258400","doi-asserted-by":"publisher","DOI":"10.1176\/appi.prcp.20180006"},{"key":"bibr5-20552076241258400","author":"Cioe K","journal-title":"J Subst Abuse Treat"},{"key":"bibr6-20552076241258400","author":"Duncan 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