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Secondary aims are the intervention's impact on clinical, physiological, psychological, and economic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, single-blind, randomized controlled trial will involve 78 participants with Progressive Multiple Sclerosis. All participants will complete 10 in-hospital rehabilitation sessions (1\u2005hour\/day, three days\/week). The experimental group will receive an additional 12-week home-based Digital Telerehabilitation (3 sessions\/week), while the control group general self-management instructions. Based on primary and secondary outcomes, a blinded rater will evaluate participants before and after rehabilitation and at 12 and 24 weeks follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Integrating home-based Digital Telerehabilitation is expected to mitigate the progression of disability, promote self-management, and reduce healthcare costs, offering a cost-effective and accessible solution for managing Progressive Multiple Sclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study will provide essential insights into the role of Digital Telerehabilitation in the hybrid care model to manage Progressive Multiple Sclerosis, with the potential to guide clinical practice and inform health policy. The physiological and economic evaluations will further clarify the benefits and cost-effectiveness of the intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      This trial was registered in ClinicalTrials.gov (NCT06485115; URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT06485115?cond=NCT06485115%26rank=1\">https:\/\/clinicaltrials.gov\/study\/NCT06485115?cond=NCT06485115&amp;rank=1<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  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