{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:09:18Z","timestamp":1785769758768,"version":"3.56.0"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ningbo Municipal Key Laboratory for Philosophy and Social Sciences","award":["SY2024-007"],"award-info":[{"award-number":["SY2024-007"]}]},{"name":"Zhejiang Science and Technology Plan for Disease Prevention and Control","award":["2025JK271"],"award-info":[{"award-number":["2025JK271"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DIGITAL HEALTH"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It's well known that obesity is a significant risk factor for dyslipidemia in the general population, but research related to individuals with mental disorders remains scarce. This study aimed to investigate the association between body mass index (BMI) and dyslipidemia among adult patients with severe mental disorders (SMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We implemented a cross-sectional study based on electronic health records. A total of 1145 adult SMD patients who underwent health examinations in 2022 were selected as study subjects. The multivariate logistic regression was used to explore association between BMI and dyslipidemia (including specific lipid abnormalities), and the exposure-response curves were plotted for whole population and subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the study subjects, 574 SMD patients had dyslipidemia. Compared with patients of normal weight, underweight was negatively associated with dyslipidemia (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      = 0.47, 95%\n                      <jats:italic toggle=\"yes\">CI<\/jats:italic>\n                      : 0.24\u20130.94), while overweight (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      = 1.75, 95%\n                      <jats:italic toggle=\"yes\">CI<\/jats:italic>\n                      : 1.33\u20132.30) and obesity (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      = 2.26, 95%\n                      <jats:italic toggle=\"yes\">CI<\/jats:italic>\n                      : 1.59\u20133.21) were positively associated with dyslipidemia. The\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      per 1.0\u2005kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      increases in BMI was 1.11 (95%\n                      <jats:italic toggle=\"yes\">CI<\/jats:italic>\n                      : 1.08\u20131.15). The exposure-response curves indicated that associations between BMI and dyslipidemia generally followed an S-shaped curves. Across different subgroups, the association exhibited variations, with greater strength observed among females, individuals aged \u226560 years, and those with hypertension, diabetes, and mental retardation accompanied by mental disorders. Associations between BMI and specific blood lipid abnormalities varied across populations. However, there were no significant interactions between all subgroup factors and BMI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the management of SMD patients, it is crucial to strengthen weight control and implement targeted interventions based on individual characteristics and specific types of dyslipidemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552076261416726","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:15:37Z","timestamp":1785557737000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between BMI and dyslipidemia in patients with severe mental disorders: An electronic health record study"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-7113","authenticated-orcid":false,"given":"Kangjun","family":"Wu","sequence":"first","affiliation":[{"name":"Zhenhai District Center for Disease Control and Prevention"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7310-2652","authenticated-orcid":false,"given":"Yujian","family":"Lu","sequence":"additional","affiliation":[{"name":"Zhenhai District Center for Disease Control and Prevention"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhenhai District Center for Disease Control and Prevention"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3041-4449","authenticated-orcid":false,"given":"Anping","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhenhai District Center for Disease Control and Prevention"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4480-667X","authenticated-orcid":false,"given":"Yuefang","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhenhai District Center for Disease Control and Prevention"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1191-7898","authenticated-orcid":false,"given":"Xiandong","family":"Shen","sequence":"additional","affiliation":[{"name":"Zhenhai District Center for Disease Control and Prevention"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1716-715X","authenticated-orcid":false,"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"Center for Intelligent Health, Zhenhai District Health Bureau, Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"221","article-title":"Chinese Guidelines for lipid management (2023)","volume":"51","author":"Joint Committee on the Chinese Guidelines for Lipid Management","year":"2023","unstructured":"Joint Committee on the Chinese Guidelines for Lipid Management. Chinese Guidelines for lipid management (2023). Zhonghua Xin Xue Guan Bing Za Zhi 2023; 51: 221\u2013255.","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx144"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2021.102583"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-024-05848-3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2023.05.016"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.081"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000973"},{"key":"e_1_3_3_9_2","first-page":"1237","article-title":"Guideline for diagnosis and treatment of obesity (2024 edition)","volume":"23","author":"Department of Medical Administration, National Health Commission of the People\u2019s Republic of China","year":"2024","unstructured":"Department of Medical Administration, National Health Commission of the People\u2019s Republic of China. Guideline for diagnosis and treatment of obesity (2024 edition). Chin J Dig Surg 2024; 23: 1237\u20131260.","journal-title":"Chin J Dig Surg"},{"key":"e_1_3_3_10_2","first-page":"599","article-title":"Analysis of the dose-response relationship between body mass Index and the strength of association with dyslipidemia among community residents of Wuhan","volume":"41","author":"Liang Y","year":"2024","unstructured":"Liang Y, Tang C, Yu Y, et al. Analysis of the dose-response relationship between body mass Index and the strength of association with dyslipidemia among community residents of Wuhan. Chin J Soc Med 2024; 41: 599\u2013604.","journal-title":"Chin J Soc Med"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22551-y"},{"key":"e_1_3_3_12_2","unstructured":"National Health Commission of the People\u2019s Republic of China. Standards for the Management and Treatment of Severe Mental Disorders (2018 Edition). Published online May 28 2018. Accessed December 14 2024. http:\/\/www.nhc.gov.cn\/jkj\/s5888\/202111\/6047ebb879e04c9fb5d5d2df78a55dff\/files\/9c4139ddfd7244b0b810c48ad63e957e.pdf."},{"key":"e_1_3_3_13_2","unstructured":"National Health Commission of the People\u2019s Republic of China. National Basic Public Health Service Standards (Third Edition). Published online February 28 2017. Accessed December 14 2024. http:\/\/www.nhc.gov.cn\/ewebeditor\/uploadfile\/2017\/04\/20170417104506514.pdf."},{"key":"e_1_3_3_14_2","first-page":"603","article-title":"2024 Chinese guidelines for the management of hypertension","volume":"32","author":"Chinese hypertension guidelines revision committee","year":"2024","unstructured":"Chinese hypertension guidelines revision committee. 2024 Chinese guidelines for the management of hypertension. Chin J Hypertens 2024; 32: 603\u2013700.","journal-title":"Chin J Hypertens"},{"key":"e_1_3_3_15_2","first-page":"16","article-title":"Guideline for the prevention and treatment of diabetes mellitus in China (2024 edition)","volume":"17","author":"Chinese Diabetes Society","year":"2025","unstructured":"Chinese Diabetes Society. Guideline for the prevention and treatment of diabetes mellitus in China (2024 edition). Chin J Diabetes Mellit 2025; 17: 16\u2013139.","journal-title":"Chin J Diabetes Mellit"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1188212"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03327-3"},{"key":"e_1_3_3_18_2","first-page":"27","article-title":"The effects of the interaction between BMI and dyslipidemia on hypertension in adults","volume":"12","author":"Tang N","year":"2022","unstructured":"Tang N, Ma J, Tao R, et al. The effects of the interaction between BMI and dyslipidemia on hypertension in adults. Sci Rep 2022; 12: 27.","journal-title":"Sci Rep"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14235174"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-023-01167-2"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.11.001"},{"key":"e_1_3_3_22_2","first-page":"16","article-title":"Trends in insulin resistance: insights into mechanisms and therapeutic strategy","volume":"7","author":"Li M","year":"2022","unstructured":"Li M, Chi X, Wang Y, et al. Trends in insulin resistance: insights into mechanisms and therapeutic strategy. Signal Transduct Target Ther 2022; 7: 16.","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30416-X"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/11786388211016842"},{"key":"e_1_3_3_25_2","first-page":"324","article-title":"Research progress on the influence of sex differences on the action of psychotropic drugs","volume":"26","author":"Zhang S","year":"2021","unstructured":"Zhang S, Hu L, Shao H, et al. Research progress on the influence of sex differences on the action of psychotropic drugs. Chin J Clin Pharmacol Ther 2021; 26: 324\u2013331.","journal-title":"Chin J Clin Pharmacol Ther"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-09172-9"},{"key":"e_1_3_3_27_2","first-page":"195","article-title":"A cross-sectional study on the prevalence and related factors of dyslipidemia among adults in anhui province, in 2015","volume":"41","author":"Xu W","year":"2020","unstructured":"Xu W, Xing XY, He Q, et al. A cross-sectional study on the prevalence and related factors of dyslipidemia among adults in anhui province, in 2015. Chin J Epidemiol 2020; 41: 195\u2013200.","journal-title":"Chin J Epidemiol"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30425-5"}],"container-title":["DIGITAL HEALTH"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20552076261416726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20552076261416726","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20552076261416726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:21:03Z","timestamp":1785766863000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20552076261416726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":27,"alternative-id":["10.1177\/20552076261416726"],"URL":"https:\/\/doi.org\/10.1177\/20552076261416726","relation":{},"ISSN":["2055-2076","2055-2076"],"issn-type":[{"value":"2055-2076","type":"print"},{"value":"2055-2076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"article-number":"20552076261416726"}}