{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:23:21Z","timestamp":1777551801133,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Changsha Science and Technology Plan Project","award":["No. kq2004112"],"award-info":[{"award-number":["No. kq2004112"]}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["No. 2022JJ70094"],"award-info":[{"award-number":["No. 2022JJ70094"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Innovation Platform Project of Department of Science and Technology of Hunan Province","award":["No. 2023Sk4056"],"award-info":[{"award-number":["No. 2023Sk4056"]}]},{"name":"Key Project of Hunan Provincial Department of Education","award":["No. 20A298"],"award-info":[{"award-number":["No. 20A298"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DIGITAL HEALTH"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Early and accurate diagnosis of pulmonary tuberculosis (PTB) is critical for disease control. This study aimed to develop and validate a clinical prediction model to differentiate adult inpatients with suspected PTB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort of 602 adults admitted to Changsha Central Hospital (January\u2013October 2019) with suspected PTB was randomly divided into a modeling group (n\u2009=\u2009421) and an internal validation group (n\u2009=\u2009181). Univariate and multivariate logistic regression analyses in the modeling cohort identified independent clinical and radiological predictors. Model performance was assessed by the area under the receiver operating characteristic curve (AUC), calibration (Hosmer\u2013Lemeshow test), and decision curve analysis. External validation was performed using 213 similar patients from Hunan Chest Hospital (January\u2013October 2019).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five independent predictors were retained: age (years), erythrocyte sedimentation rate (mm\/h), upper-lobe or dorsal-segment infiltration on chest imaging, presence of multifocal polymorphic pulmonary lesions, and pleural thickening (all p\u2009&lt;\u20090.05). In the modeling cohort, AUC = 0.977 (95% confidence interval (CI): 0.964\u20130.989); at the optimal cutoff probability of 0.611, sensitivity was 95.9% and specificity 89.4%. Calibration was satisfactory in both internal (Hosmer\u2013Lemeshow p\u2009=\u20090.815) and external (p\u2009=\u20090.973) validation cohorts. Decision curve analysis demonstrated net clinical benefit across relevant threshold probabilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The proposed five-variable model exhibited excellent discrimination, calibration, and clinical utility in both internal and external cohorts. Its simplicity and reliance on routinely available data make it a practical adjunct for clinicians in diagnosing PTB among adults with suspected disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552076261418844","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:04:18Z","timestamp":1771005858000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and validation of a diagnostic clinical prediction model for suspected pulmonary tuberculosis in adults: A retrospective analysis"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5357-8717","authenticated-orcid":false,"given":"Daiyan","family":"Fu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Guangxi Medical University"},{"name":"The Fifth Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Hunan Normal University\/Hunan Provincial People's Hospital, Changsha, China"},{"name":"Department of Pulmonary and Critical Care Medicine, Xingsha Branch of Hunan Provincial People's Hospital\/People's Hospital of Changsha County, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3893-3477","authenticated-orcid":false,"given":"Tian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Xingsha Branch of Hunan Provincial People's Hospital\/People's Hospital of Changsha County, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Changsha Central Hospital Affiliated to University of South China\/Changsha Central Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minmin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Hunan Chest Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Yi","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Hunan Normal University\/Hunan Provincial People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifang","family":"Teng","sequence":"additional","affiliation":[{"name":"The Fifth Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Hunan Normal University\/Hunan Provincial People's Hospital, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiguo","family":"Dai","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruicheng","family":"Hu","sequence":"additional","affiliation":[{"name":"The Fifth Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Hunan Normal University\/Hunan Provincial People's Hospital, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaying","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Scientific Research, The First Affiliated Hospital of Hunan Normal University\/Hunan Provincial People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Fifth Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Hunan Normal University\/Hunan Provincial People's Hospital, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2953-0772","authenticated-orcid":false,"given":"Zhiyi","family":"He","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangxi Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"World Health Organizaiton. 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