{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T16:28:59Z","timestamp":1786811339229,"version":"build-2736575974"},"reference-count":74,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DIGITAL HEALTH"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Artificial intelligence (AI), extended reality (XR), and socially assistive robotics (SAR) are each advancing Alzheimer\u2019s disease (AD) research and care at a rapid pace. Yet despite substantial progress within each domain, clinical implementation remains weakly integrated across diagnostic, therapeutic, and care functions, producing islands of innovation rather than coordinated care systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a machine-assisted semantic\u2013bibliometric synthesis of 2,636 publications on AI-, immersive technology\/VR-, and SAR-enabled approaches to AD diagnosis, intervention, and care published between 2021 and 2025. Available title\u2013abstract metadata were encoded using SBERT embeddings, projected via UMAP, and clustered using K-Means to characterize the functional topology of the field. From this mapped corpus, we selected a semantically central subset of 50 studies for high-fidelity full-text synthesis, preserving cross-domain representativeness while maintaining interpretive tractability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mapped landscape suggests a three-part pattern of architectural separation. Precision neuroimaging (Cluster C4, 22%) functions primarily as a state-oriented diagnostic domain. Immersive therapeutics (Cluster C2, 48%), the largest cluster, increasingly incorporate adaptive personalization but remain weakly connected to biomarker-based stratification. Embodied robotic care (Cluster C5, 10%) addresses behavioral stabilization with little longitudinal coupling to upstream sensing. Across all three domains, high component-level sophistication coexists with limited evidence of cross-layer coordination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Contemporary digital solutions for AD remain predominantly siloed and state-oriented rather than longitudinally integrated. We synthesize these observations into a conceptual Closed-Loop Architecture, proposed as a roadmap for future integrated digital dementia care. Advancing this agenda will depend on interoperable infrastructure, longitudinal modeling, and prospective cross-layer evaluation\u2014not solely on further isolated gains in classification accuracy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552076261479403","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T16:38:01Z","timestamp":1786639081000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bridging the islands of innovation: A machine-assisted Semantic\u2013Bibliometric review and conceptual roadmap for closed-loop digital dementia care"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6523-1676","authenticated-orcid":false,"given":"Hairong","family":"Wang","sequence":"first","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8108-1997","authenticated-orcid":false,"given":"Xingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12816"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0721-9"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01382-x"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2014-002977"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1109\/BIBM58861.2023.10385707"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0300-7"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2020.101694"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10462-024-11041-5"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12134"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30071-5"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.2196\/55897"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-020-0253-3"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-024-00998-w"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210672"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.2196\/59195"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1496382"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101633"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000529849"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1141460"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.03.018"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02783-w"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102497"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa159"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa3487"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_3_5_32_2","article-title":"OpenAlex: a fully-open index of scholarly works, authors, venues, institutions, and concepts","author":"Priem J","year":"2022","unstructured":"Priem J, Piwowar H, Orr R. 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