{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:41:11Z","timestamp":1753882871916,"version":"3.41.2"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal - Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:p> Risk assessment for natalizumab-associated progressive multifocal leukoencephalopathy (Nat-PML) comprises the anti-JC virus (JCV) antibody index (AI). The anti-JCV AI was longitudinally determined in a natalizumab-treated MS cohort (Nat-MS, n\u2009=\u2009468) and samples of Nat-PML patients ( n\u2009=\u200915). In Nat-MS, the median AI was 0.8 (25th to 75th percentile, 0.2\u20132.8) with an intra-individual coefficient of variation (CV) of 9.8% (4.8\u201317.6). Patients with an AI\u2009\u2264\u20090.9 exhibited higher CV. The AI was higher (3.4 (3.1\u20133.6)) in samples before Nat-PML diagnosis than in seropositive Nat-MS (2.4 (1.0\u20133.4), n\u2009=\u2009298, p\u2009=\u20090.010). AIs\u2009\u2265\u20093.0 were associated with a 14.5-fold (95% CI 2.3\u201390.4) increased PML risk ( p\u2009=\u20090.002). Groups with an AI below 1.5 exhibit higher variability or even serostatus fluctuation. AI dynamics require further investigation. <\/jats:p>","DOI":"10.1177\/2055217316630008","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T01:07:49Z","timestamp":1454980069000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Longitudinal analyses of anti-JCV antibody index for risk assessment of progressive multifocal leukoencephalopathy"],"prefix":"10.1177","volume":"2","author":[{"given":"A.","family":"Salmen","sequence":"first","affiliation":[{"name":"Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"von Ahsen","sequence":"additional","affiliation":[{"name":"Medizinisches Labor Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.K.","family":"Trampe","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Hoepner","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Plavina","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Subramanyam","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kuesters","sequence":"additional","affiliation":[{"name":"Biogen, Cambridge, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany; Current address: Ambulantes Neurozentrum, Inselspital, Bern University Hospital, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"key":"bibr1-2055217316630008","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107829"},{"key":"bibr2-2055217316630008","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24286"},{"key":"bibr3-2055217316630008","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182583022"},{"key":"bibr4-2055217316630008","doi-asserted-by":"crossref","unstructured":"Schwab N, Schneider-Hohendorf T, Pignolet B, et\u00a0al. PML risk stratification using anti-JCV antibody index and L-selectin. Mult Scler 2015. Available at: DOI:10.1177\/1352458515607651.","DOI":"10.1177\/1352458515607651"},{"key":"bibr5-2055217316630008","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304332"},{"key":"bibr6-2055217316630008","doi-asserted-by":"crossref","unstructured":"Vennegoor A, van Rossum JA, Polman CH, et\u00a0al. Longitudinal JCV serology in multiple sclerosis patients preceding natalizumab-associated progressive multifocal leukoencephalopathy. 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