{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:24:12Z","timestamp":1775183052548,"version":"3.50.1"},"reference-count":9,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal - Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Neurofilament light chain (NF-L) levels reflect axonal damage in different conditions, including demyelinating disorders. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p> We aimed to compare serum NF-L levels in patients with aquaporin-4 antibodies (AQP4-Ab), myelin oligodendrocyte antibodies (MOG-Ab) and seronegative cases with neuromyelitis optica spectrum disorders and related disorders. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We analysed AQP4-Ab and MOG-Ab with cell-based assay and NF-L with ultrasensitive electrochemiluminescence immunoassay. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Median NF-L levels were increased in 25 AQP4-Ab-positive patients (59 pg\/ml) as compared with 22 MOG-Ab-positive cases (25 pg\/ml), 52 seronegative patients (18 pg\/ml), 25 multiple sclerosis patients (12 pg\/ml) and 14 healthy controls (12 pg\/ml). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Increased serum levels of NF-L in patients with AQP4-Ab or MOG-Ab might reflect an ongoing axonal damage and a more malignant disease course. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2055217317743098","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T11:22:43Z","timestamp":1511349763000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Serum Neurofilament Light Chain in NMOSD and Related Disorders: Comparison According to Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Antibodies Status"],"prefix":"10.1177","volume":"3","author":[{"given":"Mariotto","family":"S","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy"},{"name":"Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farinazzo","family":"A","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monaco","family":"S","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gajofatto","family":"A","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zanusso","family":"G","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schanda","family":"K","sequence":"additional","affiliation":[{"name":"Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Capra","family":"R","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mancinelli","family":"C","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonora","family":"A","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, AOUI Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bombardi","family":"R","sequence":"additional","affiliation":[{"name":"Neurology Unit, St Bassano Hospital, Bassano del Grappa, Vicenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reindl","family":"M","sequence":"additional","affiliation":[{"name":"Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferrari","family":"S","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"bibr1-2055217317743098","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13274"},{"key":"bibr2-2055217317743098","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24954"},{"key":"bibr3-2055217317743098","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-184"},{"key":"bibr4-2055217317743098","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.11.013"},{"key":"bibr5-2055217317743098","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"bibr6-2055217317743098","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075091"},{"key":"bibr7-2055217317743098","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e2414b"},{"key":"bibr8-2055217317743098","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-312676"},{"key":"bibr9-2055217317743098","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.10.008"}],"container-title":["Multiple Sclerosis Journal - Experimental, Translational and Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2055217317743098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2055217317743098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2055217317743098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T14:40:36Z","timestamp":1740840036000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2055217317743098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,22]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1177\/2055217317743098"],"URL":"https:\/\/doi.org\/10.1177\/2055217317743098","relation":{},"ISSN":["2055-2173","2055-2173"],"issn-type":[{"value":"2055-2173","type":"print"},{"value":"2055-2173","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,22]]},"article-number":"2055217317743098"}}