{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:51:52Z","timestamp":1761709912501,"version":"3.41.2"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"This research was supported by Roche Argentina","award":["none"],"award-info":[{"award-number":["none"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal - Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p> We aimed to examine treatment interventions implemented in patients experiencing neuromyelitis optica spectrum disorders (NMOSD) attacks (frequency, types, and response). <\/jats:p><jats:sec><jats:title>Methods<\/jats:title><jats:p> Retrospective study. Data on patient demographic, clinical and radiological findings, and administered treatments were collected. Remission status (complete [CR], partial [PR], no remission [NR]), based on changes in the EDSS score was evaluated before treatment, during attack, and at 6\u2009months. CR was analyzed with a generalized estimating equations (GEEs) model. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> A total of 131 patients (120 NMOSD and 11 myelin oligodendrocyte glycoprotein-antibody-associated diseases [MOGAD]), experiencing 262 NMOSD-related attacks and receiving 270 treatments were included. High-dose steroids (81.4%) was the most frequent treatment followed by plasmapheresis (15.5%). CR from attacks was observed in 47% (105\/223) of all treated patients. During the first attack, we observed CR:71.2%, PR:16.3% and NR:12.5% after the first course of treatment. For second, third, fourth, and fifth attacks, CR was observed in 31.1%, 10.7%, 27.3%, and 33.3%, respectively. Remission rates were higher for optic neuritis vs. myelitis (p\u2009&lt;\u20090.001). Predictor of CR in multivariate GEE analysis was age in both NMOSD (OR\u2009=\u20092.27, p\u2009=\u20090.002) and MOGAD (OR\u2009=\u20091.53, p\u2009=\u20090.03). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> This study suggests individualization of treatment according to age and attack manifestation. The outcome of attacks was generally poor. <\/jats:p><\/jats:sec>","DOI":"10.1177\/20552173211032334","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T17:35:45Z","timestamp":1629480945000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessing attacks and treatment response rates among adult patients with NMOSD and MOGAD: Data from a nationwide registry in Argentina"],"prefix":"10.1177","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-5726","authenticated-orcid":false,"given":"Edgar","family":"Carnero Contentti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo A","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Pablo","family":"Pettinicchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Criniti","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Department of Neurosciences, Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Pappolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimena","family":"Miguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Patrucco","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital Italiano de Buenos Aires, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgardo","family":"Cristiano","sequence":"additional","affiliation":[{"name":"Centro de Esclerosis M\u00faltiple de Buenos Aires, CABA, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Liwacki","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universitaria Reina Fabiola, C\u00f3rdoba, Argentina"},{"name":"Servicio de Neurolog\u00eda, Hospital C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Tkachuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda E","family":"Balbuena","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neuroinmunolog\u00eda y Enfermedades Desmielinizantes, Servicio de Neurolog\u00eda, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, CABA, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Vrech","sequence":"additional","affiliation":[{"name":"Departamento de Enfermedades desmielinizantes, Sanatorio Allende, C\u00f3rdoba, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"Deri","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Diabaid, CABA, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Correale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4142-8375","authenticated-orcid":false,"given":"Mariano","family":"Marrodan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda C","family":"Ysrraelit","sequence":"additional","affiliation":[{"name":"Departamento de Neurolog\u00eda, FLENI, CABA, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felisa","family":"Leguizamon","sequence":"additional","affiliation":[{"name":"Hospital de Agudos, Dr. Teodoro \u00c1lvarez, CABA, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5716-6082","authenticated-orcid":false,"given":"Geraldine","family":"Luetic","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias de Rosario, Santa Fe, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda L","family":"Menichini","sequence":"additional","affiliation":[{"name":"Sanatorio Brit\u00e1nico, Rosario, Santa Fe, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dar\u00edo","family":"Tavolini","sequence":"additional","affiliation":[{"name":"INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Mainella","sequence":"additional","affiliation":[{"name":"Hospital Espa\u00f1ol de Rosario, Santa Fe, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Zanga","sequence":"additional","affiliation":[{"name":"Unidad Asistencial C\u00e9sar Milstein, CABA, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Burgos","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital San Bernardo, Salta, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Hryb","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital Carlos G. Durand, CABA, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Barboza","sequence":"additional","affiliation":[{"name":"Hospital Central de Mendoza, Mendoza, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Lazaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9955-8343","authenticated-orcid":false,"given":"Ricardo","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora Fern\u00e1ndez","family":"Liguori","sequence":"additional","affiliation":[{"name":"Sanatorio G\u00fcemes, CABA, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora","family":"Nadur","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neuroinmunolog\u00eda y Enfermedades Desmielinizantes, Servicio de Neurolog\u00eda, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, CABA, Buenos Aires, Argentina"},{"name":"Hospital Naval, CABA, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8645-6134","authenticated-orcid":false,"given":"An\u00edbal","family":"Chertcoff","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Enfermedades Desmielinizantes, Hospital Brit\u00e1nico, CABA, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Alonso Serena","sequence":"additional","affiliation":[{"name":"Servicio de Cl\u00ednica M\u00e9dica, Hospital Italiano de Buenos Aires, CABA, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Caride","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, Department of Neurosciences, Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Center, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"},{"name":"Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan I","family":"Rojas","sequence":"additional","affiliation":[{"name":"Centro de Esclerosis M\u00faltiple de Buenos Aires, CABA, Buenos Aires, Argentina"},{"name":"Servicio de Neurolog\u00eda, Hospital Universitario de CEMIC, CABA, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"bibr1-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"bibr2-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102428"},{"key":"bibr3-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0214-9"},{"key":"bibr4-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000468"},{"key":"bibr5-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005560"},{"key":"bibr6-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316880"},{"key":"bibr7-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx276"},{"key":"bibr8-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0112-x"},{"key":"bibr9-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8596-7"},{"key":"bibr10-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102742"},{"key":"bibr11-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-04230-6"},{"key":"bibr12-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06811"},{"key":"bibr13-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103022"},{"key":"bibr14-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.05.004"},{"key":"bibr15-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2017-001787"},{"key":"bibr16-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1144-2"},{"key":"bibr17-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"bibr18-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318248dec1"},{"key":"bibr19-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"bibr20-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000089"},{"key":"bibr21-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001367"},{"key":"bibr22-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24554"},{"key":"bibr23-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2015.04.006"},{"key":"bibr24-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1633896"},{"key":"bibr25-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000504"},{"key":"bibr26-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2016.09.011"},{"key":"bibr27-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.03.016"},{"key":"bibr28-20552173211032334","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.585471"},{"key":"bibr29-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz054"},{"key":"bibr30-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2016.02.014"},{"key":"bibr31-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1525-1"},{"key":"bibr32-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316286"},{"key":"bibr33-20552173211032334","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00537"},{"key":"bibr34-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515581438"},{"key":"bibr35-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000572"},{"key":"bibr36-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-14"},{"key":"bibr37-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0718-0"},{"key":"bibr38-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.127"},{"key":"bibr39-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30392-6"},{"key":"bibr40-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515620934"},{"key":"bibr41-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000965"},{"journal-title":"Front Immunol","year":"2021","author":"Chang X","key":"bibr42-20552173211032334"},{"key":"bibr43-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26067"},{"key":"bibr44-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102449"},{"key":"bibr45-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000607"},{"key":"bibr46-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516685416"},{"key":"bibr47-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09699-2"},{"key":"bibr48-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102258"},{"key":"bibr49-20552173211032334","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25909"},{"key":"bibr50-20552173211032334","first-page":"10","author":"Siritho S","year":"2020","journal-title":"J Neurol"}],"container-title":["Multiple Sclerosis Journal - Experimental, Translational and Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20552173211032334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20552173211032334","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20552173211032334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T09:47:32Z","timestamp":1740822452000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20552173211032334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1177\/20552173211032334"],"URL":"https:\/\/doi.org\/10.1177\/20552173211032334","relation":{},"ISSN":["2055-2173","2055-2173"],"issn-type":[{"type":"print","value":"2055-2173"},{"type":"electronic","value":"2055-2173"}],"subject":[],"published":{"date-parts":[[2021,7]]},"article-number":"20552173211032334"}}