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Differences in month of birth between cases and controls were analyzed using logistic regression and examined for effect modification by calendar year and geographic region at birth. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Males had a reduced risk of multiple sclerosis if born in the winter and increased risk if born in the early fall. Individuals born before 1960 had an increased risk if born in summer or fall. Being born in late summer and early fall was associated with more severe disease. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> We identified a birth cohort effect on the association between the month of birth and multiple sclerosis, with a more significant effects for births before 1960. 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