{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:00:32Z","timestamp":1789524032157,"version":"build-2803163510"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal - Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p> The phenotypic spectrum of myelin oligodendrocyte glycoprotein (MOG)-IgG associated disorders (MOGAD) has broadened in the past few years, and atypical phenotypes are increasingly recognized. Febrile meningoencephalitis has rarely been reported as a feature of MOGAD and represents a diagnostic challenge. We report the case of 24-year-old women with high-grade fever, meningoencephalomyelitis, and persistently positive MOG-IgG, for whom an extensive infectious work-up was negative and who responded to high-dose intravenous methylprednisolone. The full clinical spectrum of MOGAD is yet to be completely elucidated. In patients presenting with febrile meningoencephalitis, MOG-IgG testing should be considered particularly if infectious work-up is negative. <\/jats:p>","DOI":"10.1177\/20552173221148911","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T11:25:17Z","timestamp":1672745117000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["High fever in myelin oligodendrocyte  glycoprotein-associated disorder (MOGAD):  A diagnostic challenge"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6431-0727","authenticated-orcid":false,"given":"Chadi","family":"Azar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Akiki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-028X","authenticated-orcid":false,"given":"Sara F","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3824-9859","authenticated-orcid":false,"given":"Anthony","family":"Kerbage","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-2332","authenticated-orcid":false,"given":"Gabrielle","family":"Macaron","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon"},{"name":"Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"bibr1-20552173221148911","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00218-0"},{"key":"bibr2-20552173221148911","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102759"},{"key":"bibr3-20552173221148911","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519840746"},{"key":"bibr4-20552173221148911","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0719-z"},{"key":"bibr5-20552173221148911","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1144-2"},{"key":"bibr6-20552173221148911","doi-asserted-by":"publisher","DOI":"10.1177\/2329048X20942442"},{"key":"bibr7-20552173221148911","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2021.03.006"},{"key":"bibr8-20552173221148911","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102748"},{"key":"bibr9-20552173221148911","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012599"},{"key":"bibr10-20552173221148911","doi-asserted-by":"publisher","DOI":"10.3390\/children8040280"}],"container-title":["Multiple Sclerosis Journal - Experimental, Translational and Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20552173221148911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20552173221148911","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20552173221148911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T18:25:32Z","timestamp":1740767132000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20552173221148911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1177\/20552173221148911"],"URL":"https:\/\/doi.org\/10.1177\/20552173221148911","relation":{},"ISSN":["2055-2173","2055-2173"],"issn-type":[{"value":"2055-2173","type":"print"},{"value":"2055-2173","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"20552173221148911"}}