{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:42:42Z","timestamp":1753882962989,"version":"3.41.2"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal - Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p> The primary objective was to evaluate long-term treatment persistence and safety of natalizumab in Finnish multiple sclerosis patients. The secondary objectives were to assess patient characteristics, use of natalizumab-related safety protocol, and treatment persistence in patients with different anti-John Cunningham virus antibody statuses (John Cunningham virus status). <\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p> All adult multiple sclerosis patients in the Finnish multiple sclerosis register who started natalizumab between 1\/2006 and 12\/2018 were included in this study and followed retrospectively until treatment discontinuation or end of follow-up (12\/2019). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> In total, 850 patients were included. Median duration of natalizumab treatment was 7.8 years in John Cunningham virus negative ( n\u2009=\u2009229) and 2.1 years in John Cunningham virus positive patients ( n\u2009=\u2009115; p\u2009&lt;\u20090.001). The most common cause for treatment discontinuation was John Cunningham virus positivity. After natalizumab discontinuation, patients who had a washout duration of less than 6 weeks had fewer relapses during the first 6 months ( p\u2009=\u20090.012) and 12 months ( p\u2009=\u20090.005) compared with patients who had a washout duration of over 6 weeks. During the median follow-up of 3.6 years, 76% of patients remained stable or improved on their Expanded Disability Status Scale. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Treatment persistence was very high among John Cunningham virus negative patients. The study supports long-term effectiveness of natalizumab and a washout duration of less than 6 weeks after discontinuation. <\/jats:p><\/jats:sec>","DOI":"10.1177\/20552173231204466","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T16:52:06Z","timestamp":1696438326000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-world treatment outcomes and safety of natalizumab in Finnish multiple sclerosis patients"],"prefix":"10.1177","volume":"9","author":[{"given":"Auli","family":"Verkkoniemi-Ahola","sequence":"first","affiliation":[{"name":"Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi","family":"Hartikainen","sequence":"additional","affiliation":[{"name":"Neuro Center, Neurology Outpatient Clinic, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Hassi","sequence":"additional","affiliation":[{"name":"Biogen Finland Oy, Espoo, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3697-4961","authenticated-orcid":false,"given":"Hanna","family":"Kuusisto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tampere University Hospital, Tampere, Finland"},{"name":"Kanta-H\u00e4me Central Hospital, H\u00e4meenlinna, Finland"},{"name":"Department of Health and Social Management, University of Eastern Finland, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-3502","authenticated-orcid":false,"given":"Sanni","family":"Lahdenper\u00e4","sequence":"additional","affiliation":[{"name":"Biogen Finland Oy, Espoo, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Meht\u00e4l\u00e4","sequence":"additional","affiliation":[{"name":"MedEngine Oy, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matias","family":"Viitala","sequence":"additional","affiliation":[{"name":"StellarQ Ltd, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tero","family":"Ylisaukko-oja","sequence":"additional","affiliation":[{"name":"MedEngine Oy, Helsinki, Finland"},{"name":"Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-0229","authenticated-orcid":false,"given":"Merja","family":"Soilu-H\u00e4nninen","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Turku, Turku, Finland"},{"name":"Neurocenter, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"bibr1-20552173231204466","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13819"},{"key":"bibr2-20552173231204466","unstructured":"Tysabri EPAR Annex I. 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