{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:23:36Z","timestamp":1790792616220,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Biogen MA Inc.","award":["CAN-MSG-17-11120"],"award-info":[{"award-number":["CAN-MSG-17-11120"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal - Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>An increasing number of women with multiple sclerosis (wMS) are considering pregnancy. Prior studies suggest increased rate of elective cesarian sections (C-sections) in wMS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Canadian Multiple Sclerosis Pregnancy Study (CANPREG-MS) is a prospective study on pregnant wMS. This report shows comparisons between (i) CANPREG-MS wMS delivered by C-section and the general population and (ii) C-section and vaginal deliveries in this study cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CANPREG-MS has resulted in 170 deliveries with 63 by C-section. The proportion with C-sections in CANPREG-MS (37.1%) was significantly higher than that for the Canadian population (28%) ( p\u2009=\u2009.0085). The majority (66.7%) of C-sections were not planned, and typically were performed for obstetrical indications. C-sections were performed at an earlier gestational age than vaginal deliveries, although birthweight did not differ by mode of delivery in wMS. MS relapses (3.2%) and pseudo-relapses (3.2%) were rare in the first month after C-section deliveries, regardless of disease modifying therapy decisions during gestation and postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>C-sections were more common in wMS than the general population, but few were because of maternal MS. CANPREG-MS provides informative data for pregnancies in wMS with well-managed and relatively mild disease. This information is helpful to obstetrical and MS healthcare providers.<\/jats:p><\/jats:sec>","DOI":"10.1177\/20552173241285546","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T16:39:43Z","timestamp":1728405583000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Cesarian sections in women with multiple sclerosis: A Canadian prospective pregnancy study"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2987-2008","authenticated-orcid":false,"given":"Dessa","family":"Sadovnick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Criscuoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7085-1001","authenticated-orcid":false,"given":"Robert","family":"Carruthers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Devonshire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0090-597X","authenticated-orcid":false,"given":"Kristen M","family":"Krysko","sequence":"additional","affiliation":[{"name":"BARLO MS Centre, Division of Neurology, Department of Medicine, St Michael's Hospital, University of Toronto, and Li Ka Shing Knowledge Institute, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"bibr1-20552173241285546","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"bibr2-20552173241285546","unstructured":"https:\/\/mscanada.ca\/disease-modifying-therapies-dmts (accessed 2023 July 5)."},{"key":"bibr3-20552173241285546","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006384"},{"key":"bibr4-20552173241285546","unstructured":"MS Atlas, https:\/\/www.atlasofms.org\/map\/united-states-of-america\/epidemiology\/number-of-people-with-ms (accessed 2024 January 22)"},{"key":"bibr5-20552173241285546","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00426-4"},{"key":"bibr6-20552173241285546","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101867"},{"key":"bibr7-20552173241285546","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000001035"},{"key":"bibr8-20552173241285546","unstructured":"https:\/\/www.healthline.com\/health\/pregnancy\/complications-cesarean-section (accessed 2023 Aug. 15)."},{"key":"bibr9-20552173241285546","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2019.296"},{"key":"bibr10-20552173241285546","unstructured":"https:\/\/www.cihi.ca\/en\/indicators\/low-risk-caesarean-sections (accessed 2023 May 2)."},{"key":"bibr11-20552173241285546","unstructured":"https:\/\/mymsaa.org\/publications\/ms-relapse-toolkit\/pseudoexacerbation\/ (accessed 2023 Sept. 12)."},{"key":"bibr12-20552173241285546","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2377-13-37","volume":"13","author":"Learmonth YC","journal-title":"BMC Neurol 2013"},{"key":"bibr13-20552173241285546","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20170128"},{"key":"bibr14-20552173241285546","unstructured":"https:\/\/publications.gc.ca\/collections\/collection_2014\/aspc-phac\/HP7-1-2013-eng.pdf (p.26; accessed on 2023 May 12)."},{"key":"bibr15-20552173241285546","unstructured":"El Adam S, Hutcheon JA, McLeod C, et al. 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