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Two patients presented with bilateral IU. Despite targeted uveitis treatment with corticosteroids and methotrexate, both had ongoing disease activity with symptoms, and fluorescein angiographic abnormalities. Both were subsequently identified to have radiologically isolated MS in the absence of clinical demyelination. Treatment with natalizumab in isolation, led to rapid and sustained resolution of uveitis, enabling discontinuation of other immunosuppression. This case series adds evidence supporting use of alpha-4 integrins in the treatment of MS-associated uveitis, in addition to its known high-efficacy in MS. <\/jats:p>","DOI":"10.1177\/20552173241301034","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T11:03:02Z","timestamp":1733828582000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting alpha-4 integrin with natalizumab for intermediate uveitis associated with multiple sclerosis"],"prefix":"10.1177","volume":"10","author":[{"given":"Aicee Dawn","family":"Calma","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Concord Repatriation General Hospital, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Concord Repatriation General Hospital, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Sandbach","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Prince of Wales Hospital, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Riminton","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia"},{"name":"Department of Immunology, Concord Repatriation General Hospital, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-3350","authenticated-orcid":false,"given":"Stephen W","family":"Reddel","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Concord Repatriation General Hospital, Sydney, Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-9768","authenticated-orcid":false,"given":"Sudarshini","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Concord Repatriation General Hospital, Sydney, Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia"},{"name":"Translational Neuroimmunology Group, Kids Neuroscience Centre, Faculty of Medicine and Health and Brain and Mind Centre, University of Sydney, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"bibr1-20552173241301034","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000909"},{"key":"bibr2-20552173241301034","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.12.040"},{"key":"bibr3-20552173241301034","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-017-0742-1"},{"key":"bibr4-20552173241301034","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-1630-2"},{"key":"bibr5-20552173241301034","first-page":"03","volume":"23","author":"Chen YH","journal-title":"Int J Mol Sci"},{"key":"bibr6-20552173241301034","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2013"},{"key":"bibr7-20552173241301034","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0418"},{"key":"bibr8-20552173241301034","first-page":"476","volume":"235","author":"Roemer S","journal-title":"Klin Monbl Augenheilkd"},{"key":"bibr9-20552173241301034","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2024.2337839"},{"key":"bibr10-20552173241301034","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-4971-1"}],"container-title":["Multiple Sclerosis Journal - 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