{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:23:19Z","timestamp":1767651799174,"version":"3.48.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","award":["Writing grant"],"award-info":[{"award-number":["Writing grant"]}],"id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Innovations are essential to meet the needs of people with MS (PwMS), particularly in addressing delays in diagnosis and treatment, and in supporting patient self-management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the real-world use and outcomes of digital technologies and holistic management strategies for MS at a UK Centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Digital tools for PwMS included Patients Know Best (a personal health record) and CONNECTPlus\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (an educational app). Tools for healthcare professionals included Infoflex (a clinical database with MSProDiscuss for assessing disease progression). A Healthy Lifestyle Clinic was introduced to promote brain health. The impact of these interventions on time-to-diagnosis, time-to-disease-modifying therapy (DMT) initiation, non-elective admissions, and hospital costs was evaluated retrospectively from 2018 to 2023, comparing pre-intervention (2018\u20132019) with post-intervention (2020\u20132023) periods, while accounting separately for COVID-19 years (2020\u20132021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Trends indicated a higher likelihood of disease progression in patients with delayed MS diagnosis (p\u2009&lt;\u20090.001), and a reduction in time from diagnosis to DMT initiation, from an average of 23.5 to 5.8 months (p\u2009=\u20090.024), post-MS Infoflex disease management database implementation. Non-elective admissions and healthcare costs also decreased compared to neighbouring hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Digital and holistic interventions were associated with positive trends in MS care delivery. Further research is needed to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173251317020","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T14:35:36Z","timestamp":1744727736000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating patient care in multiple sclerosis: Impact of combined digital tools and holistic management strategies"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7183-4002","authenticated-orcid":false,"given":"Agne","family":"Straukiene","sequence":"first","affiliation":[{"name":"Torbay and South Devon NHS Foundation Trust"},{"name":"Faculty of Health, University of Plymouth, Plymouth, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Neurology, Torbay Hospital, Torbay and South Devon NHS Foundation Trust, Torquay, UK, Torquay, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Grundy","sequence":"additional","affiliation":[{"name":"Torbay and South Devon NHS Foundation Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn","family":"Moxon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Torbay Hospital, Torbay and South Devon NHS Foundation Trust, Torquay, UK, Torquay, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Multiple sclerosis","author":"Tafti D","year":"2022","unstructured":"Tafti D, Ehsan M, Xixis KL. Multiple sclerosis. Treasure Island (FL): StatPearls Publishing, 2022. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499849\/ (accessed December 2023)."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2017.11.013"},{"key":"e_1_3_3_4_2","unstructured":"Transforming MS for all audit and webinar 2023 https:\/\/transformingmsforall.org\/transforming-ms-for-all-audit-and-webinar\/ (accessed October 2023)."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102854"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14432"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518809326"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005347"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517751049"},{"key":"e_1_3_3_10_2","unstructured":"National Institute for Health and Care Excellence (NICE). Multiple sclerosis in adults: management. NICE guideline [NG220] https:\/\/www.nice.org.uk\/guidance\/ng220\/chapter\/Recommendations#comprehensive-review (22 June 2022 accessed October 2024)."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073.2012-044"},{"key":"e_1_3_3_12_2","unstructured":"Ellins J Coulter A. How engaged are people in their healthcare. Findings of a national telephone survey. The Health Foundation London UK. https:\/\/www.health.org.uk\/publications\/how-engaged-are-people-in-their-healthcare (2005 accessed May 2023)."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-018-3387-0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2017-007635"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15391"},{"key":"e_1_3_3_16_2","unstructured":"National Multiple Sclerosis Society. Living well with MS: diet exercise and healthy behaviors https:\/\/www.nationalmssociety.org\/Living-Well-With-MS\/Diet-Exercise-Healthy-Behaviors (accessed September 2023)."},{"key":"e_1_3_3_17_2","first-page":"55","article-title":"Interventions to improve quality of life in multiple sclerosis: new opportunities and key talking points","volume":"13","author":"Faraclas E","year":"2023","unstructured":"Faraclas E. Interventions to improve quality of life in multiple sclerosis: new opportunities and key talking points. Degener Neurol Neuromuscul Dis 2023; 13: 55\u201368.","journal-title":"Degener Neurol Neuromuscul Dis"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15940"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15980"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104858"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0284477"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518799629"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/20552076211055552"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520946005"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12010040"},{"key":"e_1_3_3_26_2","unstructured":"Patients Know Best. https:\/\/patientsknowbest.com\/patients-and-carers\/ (accessed May 2023)."},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/20552076231173531"},{"key":"e_1_3_3_28_2","unstructured":"HCI digital: MS Connect. https:\/\/www.hci.digital\/case-studies\/connectplus-app-ms-case-study\/ (accessed May 2023)."},{"key":"e_1_3_3_29_2","unstructured":"Civica Clinical Pathways (formerly Infoflex). https:\/\/www.civica.com\/en-gb\/product-pages\/patient-care-software\/ (accessed May 2023)."},{"key":"e_1_3_3_30_2","unstructured":"MSProDiscuss. https:\/\/www.health.novartis.co.uk\/resources-and-training\/neuroscience\/therapy-area\/physician-patient-interaction-tools\/msprodiscuss (accessed May 2023)."},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.2196\/16932"},{"key":"e_1_3_3_32_2","unstructured":"Multiple Sclerosis Trust 2020. 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