{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:47:23Z","timestamp":1790293643097,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Assessing and interpreting walking capacity in persons with Multiple sclerosis (PwMS) is essential in clinical practice and research \u2013 and thus for PwMS themselves \u2013 yet research evaluating cut-points is limited. The present study aims to establish cut-points for 6-min walk test (6MWT), six spot step test (SSST), and timed 25-foot walk test (T25FWT) in PwMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Classification of PwMS having walking impairments and PwMS having limited or no walking impairments was based on distinct benchmarks for each walking test, as derived from the 12-item Multiple Sclerosis Walking Scale (MSWS-12) on a 5-point Likert scale. Cut-points, area under the curve (AUC), sensitivity (Se), and specificity (Sp) were established using receiver operating characteristic curve analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009211 ambulatory PwMS were enrolled (68% females, 54\u2009\u00b1\u200911 years, patient-determined disease step 2.9\u2009\u00b1\u20091.9 [range; 0\u20137], 65.1% relapse-remitting Multiple sclerosis). The following cut-points between the two groups were established: 6MWT (446\u2005m; AUC\u2009=\u20090.82, Se\u2009=\u20090.87, Sp\u2009=\u20090.78), SSST (0.121 rounds\/s (corresponding to 8.3\u2005s); AUC\u2009=\u20090.80, Se\u2009=\u20090.84, Sp\u2009=\u20090.75), and T25FWT (1.39\u2005m\/s (corresponding to 5.5\u2005s); AUC\u2009=\u20090.79, Se\u2009=\u20090.89, Sp\u2009=\u20090.69).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cut-points discriminating PwMS having walking impairments vs. PwMS having limited or no walking impairments were identified for 6MWT (446\u2005m), SSST (8.3\u2005s), and T25FWT (5.5\u2005s).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173251324600","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T21:59:03Z","timestamp":1743112743000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cut-points of the 6-min walk test, the six spot step test, and the timed-25-foot walk test discriminating impaired from non-impaired walking capacity in persons with Multiple sclerosis"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0331-541X","authenticated-orcid":false,"given":"Camilla","family":"Juhl","sequence":"first","affiliation":[{"name":"Exercise Biology, Department of Public Health, Aarhus University, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5156-3006","authenticated-orcid":false,"given":"Kasper","family":"Byskov","sequence":"additional","affiliation":[{"name":"Exercise Biology, Department of Public Health, Aarhus University, Denmark"},{"name":"The Danish MS Hospitals, Ry and Haslev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-0429","authenticated-orcid":false,"given":"Lars G.","family":"Hvid","sequence":"additional","affiliation":[{"name":"Exercise Biology, Department of Public Health, Aarhus University, Denmark"},{"name":"The Danish MS Hospitals, Ry and Haslev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4132-2789","authenticated-orcid":false,"given":"Ulrik","family":"Dalgas","sequence":"additional","affiliation":[{"name":"Exercise Biology, Department of Public Health, Aarhus University, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1313-2056","authenticated-orcid":false,"given":"Uwe M.","family":"Pommerich","sequence":"additional","affiliation":[{"name":"Hammel Neurorehabilitation Centre, University Research Clinic, Department of Clinical Medicine, Aarhus University, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5924-2934","authenticated-orcid":false,"given":"Anders G.","family":"Skjerb\u00e6k","sequence":"additional","affiliation":[{"name":"Exercise Biology, Department of Public Health, Aarhus University, Denmark"},{"name":"The Danish MS Hospitals, Ry and Haslev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1401483"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968320907074"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/20552173231218127"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510361357"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12881"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257809"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516680749"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.60.1.31"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516630821"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1923"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53501.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13442"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000436065.97642.d2"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1191\/1352458506ms1293oa"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2014.10.011"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507082607"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585211017013"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.60.1.31"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-147"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968314521010"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512444498"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2012.08.214"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513483890"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.2217\/nmt-2018-0016"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-022-01991-4"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2013.02.0042"},{"key":"e_1_3_3_30_2","unstructured":"COSMIN. COSMIN database of systematic reviews 2023. Available from: https:\/\/www.cosmin.nl\/tools\/cosmin-taxonomy-measurement-properties\/."},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.10.001"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-021-02901-y"},{"key":"e_1_3_3_33_2","first-page":"128","article-title":"Update on distance and velocity requirements for community ambulation","volume":"33","author":"Andrews AW","year":"2010","unstructured":"Andrews AW, Chinworth SA, Bourassa M, et al. Update on distance and velocity requirements for community ambulation. J Geriatr Phys Ther 2010; 33: 128\u2013134.","journal-title":"J Geriatr Phys Ther"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.252"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073-13.1.4"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20070064"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab183"},{"key":"e_1_3_3_38_2","article-title":"Physical frailty and gait speed in community elderly: a systematic review","volume":"52","author":"Binotto MA","year":"2018","unstructured":"Binotto MA, Lenardt MH, Rodr\u00edguez-Mart\u00ednez MDC. Physical frailty and gait speed in community elderly: a systematic review. Rev Esc Enferm USP 2018; 52: e03392.","journal-title":"Rev Esc Enferm USP"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv126"}],"container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20552173251324600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20552173251324600","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20552173251324600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:13:31Z","timestamp":1767680011000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20552173251324600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1177\/20552173251324600"],"URL":"https:\/\/doi.org\/10.1177\/20552173251324600","relation":{},"ISSN":["2055-2173","2055-2173"],"issn-type":[{"value":"2055-2173","type":"print"},{"value":"2055-2173","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"20552173251324600"}}