{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:28:36Z","timestamp":1778858916194,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100031071","name":"T\u00f8mmerhandler Johannes Fogs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonden af 1870"},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["154868"],"award-info":[{"award-number":["154868"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010809","name":"Jascha Fonden","doi-asserted-by":"publisher","award":["2021-0120"],"award-info":[{"award-number":["2021-0120"]}],"id":[{"id":"10.13039\/100010809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008361","name":"Scleroseforeningen","doi-asserted-by":"publisher","award":["A42692"],"award-info":[{"award-number":["A42692"]}],"id":[{"id":"10.13039\/100008361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["21-B-0236"],"award-info":[{"award-number":["21-B-0236"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple sclerosis (MS) is characterized by impairment of physical function that is often linked to neuromuscular and cardiovascular deficits. However, the specific contributions of muscle strength and aerobic capacity to physical function in MS are not fully understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study aimed to investigate the independent roles of maximal muscle strength (MVC) and aerobic capacity (VO\n                      <jats:sub>2<\/jats:sub>\n                      peak) on lower extremity physical function, as measured by the 6-minute walk test (6MWT) and five-time sit-to-stand test (5STS) in people with MS (pwMS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a cross-sectional study, 150 pwMS underwent assessment of VO\n                      <jats:sub>2<\/jats:sub>\n                      peak, maximal voluntary contraction (MVC), and physical function (6MWT and 5STS). Regression analyses were conducted to explore the associations between physiological parameters and physical function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MVC and VO\n                      <jats:sub>2<\/jats:sub>\n                      peak were moderately associated with (i.e., explained) 6MWT (R\u00b2 = 0.40, p &lt; 0.001), yet with VO\n                      <jats:sub>2<\/jats:sub>\n                      peak (\u03b2 = 7.9, std. \u03b2 = 0.45, p &lt; 0.001) having a preferential influence compared to MVC (\u03b2\u2009=\u200948.2, std. \u03b2\u2009=\u20090.26, p\u2009&lt;\u20090.001). MVC and VO\n                      <jats:sub>2<\/jats:sub>\n                      peak were weakly associated with (i.e., explained) 5STS (R\u00b2\u2009=\u20090.14, p\u2009&lt;\u20090.001), yet with MVC (\u03b2\u2009=\u20090.06, std. \u03b2\u2009=\u20090.28, p\u2009=\u20090.004) having a preferential influence compared to VO\n                      <jats:sub>2<\/jats:sub>\n                      peak (\u03b2\u2009=\u20090.00, std. \u03b2\u2009=\u20090.16, p\u2009=\u20090.101).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both maximal muscle strength and aerobic capacity to physical function in pwMS. Maximal muscle strength was preferentially linked to performance in the 5STS test, whereas aerobic capacity was preferentially linked to performance in the 6MWT. These findings support the need for tailored exercise interventions to target specific physiological deficits during MS rehabilitation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173251326171","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T17:13:16Z","timestamp":1742577196000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Implications of maximal muscle strength and aerobic capacity for lower extremity physical function in people with multiple sclerosis\u2014a cross-sectional study"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-5967","authenticated-orcid":false,"given":"Laurits","family":"Taul-Madsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4132-2789","authenticated-orcid":false,"given":"Ulrik","family":"Dalgas","sequence":"additional","affiliation":[{"name":"Aarhus University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9519-4788","authenticated-orcid":false,"given":"Hjalte","family":"Riis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus K.","family":"Brol\u00f8s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Lundbye-Jensen","sequence":"additional","affiliation":[{"name":"University of Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-0429","authenticated-orcid":false,"given":"Lars G.","family":"Hvid","sequence":"additional","affiliation":[{"name":"Aarhus University"},{"name":"The Danish MS Hospitals, Ry and Haslev, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4410"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/11591150-000000000-00000"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/2055217318783352"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2021.03.026"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-019-1002-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104198"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231204451"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257809"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2020.111025"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-151247"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2012.683479"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13540"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514549402"},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-085241","article-title":"Study protocol: effects of exercise booster sessions on preservation of exercise-induced adaptations in persons with multiple sclerosis, a multicentre randomised controlled trial-the MS BOOSTER trial","volume":"14","author":"Taul-Madsen L","year":"2024","unstructured":"Taul-Madsen L, Hvid LG, Sellebjerg F, et al. 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