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Age-adjusted incidence and prevalence were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Age-adjusted incidence per 10\n                      <jats:sup>5<\/jats:sup>\n                      person years increased from 3.7 (95% CI 3.5\u20133.8) during the Schumacher criteria period to 9.2 (95% CI 9.0\u20139.4) during the earlier McDonald criteria. During the Current McDonald criteria incidence stabilized to 8.6 (95% CI 8.3\u20139.0). Prevalence increased from 24.3 (95% CI 22.8\u201325.8) to 241.5 (95% CI 237.3\u2013245.6) per 10\n                      <jats:sup>5<\/jats:sup>\n                      person years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both incidence and prevalence of MS increased significantly. Incidence showed a sharp increase when entering the twenty-first century, after which it stabilized. Increasing incidence was likely related to incorporation of MRI in the diagnostic criteria. Current diagnostic criteria did not further increase the incidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173251326173","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T02:43:36Z","timestamp":1742179416000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Incidence and prevalence of multiple sclerosis during eras of evolving diagnostic criteria\u2014a nationwide population-based registry study over five decades"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-0554","authenticated-orcid":false,"given":"Anna","family":"Maunula","sequence":"first","affiliation":[{"name":"University of Helsinki"},{"name":"HUS Neurocenter, Department of Neurology, Hyvink\u00e4\u00e4 Hospital, Hyvink\u00e4\u00e4, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-2849","authenticated-orcid":false,"given":"Sini M","family":"Laakso","sequence":"additional","affiliation":[{"name":"University of Helsinki"},{"name":"HUS Neurocenter, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2854-2410","authenticated-orcid":false,"given":"Matias","family":"Viitala","sequence":"additional","affiliation":[{"name":"StellarQ Ltd, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-0229","authenticated-orcid":false,"given":"Merja","family":"Soilu-H\u00e4nninen","sequence":"additional","affiliation":[{"name":"University of Turku"},{"name":"Neurocenter, Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-0483","authenticated-orcid":false,"given":"Marja-Liisa","family":"Sumelahti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1293-9325","authenticated-orcid":false,"given":"Sari","family":"Atula","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital"},{"name":"University of Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61620-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30443-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70064-8"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520970841"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2004.00326.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005612"},{"key":"e_1_3_3_8_2","first-page":"186950","article-title":"Increasing incidence in relapsing-remitting MS and high rates among young women in Finland: a thirty-year follow-up","volume":"2014","author":"Sumelahti ML","year":"2014","unstructured":"Sumelahti ML, Holmberg MHA, Murtonen A, et al. 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