{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:28:16Z","timestamp":1790144896209,"version":"4.0.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology"},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["Grant Number UL1 TR002377"],"award-info":[{"award-number":["Grant Number UL1 TR002377"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Falls in people with multiple sclerosis (pwMS) lead to morbidity and expense.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Identify clinical metrics associated with falls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-six pwMS completed fall surveys, timed 25-foot walk (T25FW), and motion analysis with Clario Opal devices. Logistic regression models were created.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age was 54.5 years (range 21\u201373), 62% (53) were female. The cohort included 58% with relapsing (50) and 42% with progressive MS (36). Those who reported falling in the last year were older (median age 58 vs 52.5,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.03) and had a higher Patient Determined Disease Step (PDDS) score (median 3 vs 1,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). Falls were associated with worse balance metrics including sway area (median 2.3 degrees\n                      <jats:sup>2<\/jats:sup>\n                      vs 1.2,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.01), jerk (median 3.3 m\n                      <jats:sup>2<\/jats:sup>\n                      \/s\n                      <jats:sup>5<\/jats:sup>\n                      vs 1.6,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.005), and slower T25FW (median 11.5\u2005s vs 8;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). A multivariable regression model based on gait aid use and T25FW time &gt;10.8\u2005s (c\u2009=\u20090.80) was derived. Having both features portended a probability of falling of 0.97, while having neither, a probability of 0.26.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Falls in pwMS are more frequent in patients who are older, have higher PDDS, slower walking, and worse balance. Gait aid use and T25FW &gt;10.8\u2005s were strongly associated with falls in the past year.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173251329825","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T15:13:33Z","timestamp":1744816413000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessing fall risk in multiple sclerosis using patient-reported outcomes and wearable gait metrics"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5856-1367","authenticated-orcid":false,"given":"Samantha A","family":"Banks","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic School of Medicine, Rochester, MN, USA"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L","family":"Howe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic School of Medicine, Rochester, MN, USA"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"},{"name":"Translational Neuroimmunology Lab, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Mandrekar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic School of Medicine, Rochester, MN, USA"},{"name":"Department of laboratory Medicine and Pathology, Mayo Clinic School of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-1462","authenticated-orcid":false,"given":"Omid","family":"Jahanian","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine &amp; Rehabilitation, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-6491","authenticated-orcid":false,"given":"Sean J","family":"Pittock","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic School of Medicine, Rochester, MN, USA"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"},{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic School of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farwa","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic School of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A","family":"Sagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Robert","family":"Spence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie A","family":"Gossman","sequence":"additional","affiliation":[{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic School of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6661-2910","authenticated-orcid":false,"given":"Eoin P","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic School of Medicine, Rochester, MN, USA"},{"name":"Cente for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"},{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic School of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhun H","family":"Kantarci","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic School of Medicine, Rochester, MN, USA"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2880-935X","authenticated-orcid":false,"given":"B Mark","family":"Keegan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic School of Medicine, Rochester, MN, USA"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8141-2394","authenticated-orcid":false,"given":"W Oliver","family":"Tobin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic School of Medicine, Rochester, MN, USA"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073.2020-014"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000200184"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10743-y"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2011.04.015"},{"key":"e_1_3_2_6_2","first-page":"496325","article-title":"Predicting falls in people with multiple sclerosis: fall history is as accurate as more complex measures","volume":"2013","author":"Cameron MH","year":"2013","unstructured":"Cameron MH, Thielman E, Mazumder R, et al. 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