{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:28:21Z","timestamp":1792891701064,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple sclerosis (MS) may have a major impact on the physical, social and psychological wellbeing of people with multiple sclerosis (pwMS) and their family members\/partners.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To measure the impact of a person's MS on the quality of life of their family members\/partner, and the associates of impact among family members, using a validated generic family-specific quality of life instrument, the Family Reported Outcome Measure (FROM-16).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An online cross-sectional study was conducted to recruit family members\/partners of pwMS through UK patient support groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 219 family members\/partners (mean age\u2009=\u200949.3 years, SD\u2009=\u200913.7; females\u2009=\u200955.3%) of pwMS (mean age\u2009=\u200950.1, SD\u2009=\u200912.5; females\u2009=\u200956.6%) completed the FROM-16. The FROM-16 mean total score was 16.9 (SD\u2009=\u20097.8), indicating \u2018a very large effect\u2019 on family members\u2019 quality of life. The increasing age of pwMS, being a male person with MS, and being a female carer were significant predictors of family impact. 50.7% of family members had FROM-16 scores \u226517. Spouses\/partners (170\/219) of pwMS reported a significant impact on their sex life compared to other relationships (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MS substantially impacts the quality of life of family members\/partners of pwMS, indicating a need to assess this impact routinely. The FROM-16 could be used to measure the MS family impact in routine practice to support family members appropriately and to include this impact in health economic appraisal and therapeutic clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173251338762","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T02:43:11Z","timestamp":1748400191000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Multiple sclerosis greatly impacts family members\/partners: Evidence using the Family Reported Outcome Measure (FROM-16)"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8158-712X","authenticated-orcid":false,"given":"Rubina","family":"Shah","sequence":"first","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-5699","authenticated-orcid":false,"given":"Sam","family":"Salek","sequence":"additional","affiliation":[{"name":"University of Hertfordshire"},{"name":"Institute of Medicines Development, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4184-2023","authenticated-orcid":false,"given":"Faraz M","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7433-4383","authenticated-orcid":false,"given":"Kennedy","family":"Otwombe","sequence":"additional","affiliation":[{"name":"Statistics and Data Management Centre, Perinatal HIV Research Unit, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J","family":"Nixon","sequence":"additional","affiliation":[{"name":"Family members research partner, Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Elaine","family":"Nixon","sequence":"additional","affiliation":[{"name":"Family members research partner, Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5898-9462","authenticated-orcid":false,"given":"Gillian","family":"Ingram","sequence":"additional","affiliation":[{"name":"Swansea Bay University Health Board"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5257-1142","authenticated-orcid":false,"given":"John R","family":"Ingram","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2143-1646","authenticated-orcid":false,"given":"Andrew Y","family":"Finlay","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"16","article-title":"Quality of life and burden in caregivers of multiple sclerosis patients","volume":"25","author":"Opara J","year":"2018","unstructured":"Opara J, Brola W. 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