{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:25:07Z","timestamp":1790144707046,"version":"4.0.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Institute of Health","award":["R01NS082347"],"award-info":[{"award-number":["R01NS082347"]}]},{"name":"National Multiple Sclerosis Society","award":["RG-1606-08768"],"award-info":[{"award-number":["RG-1606-08768"]}]},{"name":"National Multiple Sclerosis Society","award":["RG-1907-34405"],"award-info":[{"award-number":["RG-1907-34405"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Optical coherence tomography (OCT) allows evaluation of inter-eye differences (IEDs) in peri-papillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses to identify unilateral optic nerve involvement (UONI), which is included in the 2024 revised McDonald diagnostic criteria for multiple sclerosis (MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the test\u2013retest reliability of pRNFL and GCIPL thicknesses\/IEDs in people with MS, other neurological disorders, and healthy controls using Cirrus HD-OCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>509 participants underwent Cirrus HD-OCT, acquiring two macular and optic disc scans per eye within each session. Scans meeting OSCAR-IB quality control criteria were included in final analyses (959 eyes), with no clinical\/demographic exclusions (reflecting a real-world clinical setting). Reliability was assessed using coefficients of variation (COVs), intraclass correlation coefficients (ICCs), and Bland\u2013Altman limits of agreement (LOA). IED consistency was evaluated using difference-in-differences (DiDs) of test\u2013retest measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GCIPL demonstrated superior reliability (ICC: 0.998, COV: 0.40%, LOA: \u22121.29 to 1.35\u2005\u03bcm) to pRNFL (ICC: 0.989, COV: 1.18%, LOA: \u22123.59 to 3.70\u2005\u03bcm) thickness. Inter-eye absolute DiDs [pRNFL: 2.00\u2005\u03bcm (standard deviation (SD) 1.73); GCIPL: 0.64\u2005\u03bcm (SD 0.67)] were lower than IED thresholds proposed for identifying UONI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The excellent reliability of GCIPL and pRNFL thicknesses\/IEDs support OCT for identifying UONI to diagnose MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173251340957","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:28:35Z","timestamp":1747009715000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Test\u2013retest reliability of Cirrus HD-optical coherence tomography retinal layer thickness measurements in people with multiple sclerosis"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9434-8531","authenticated-orcid":false,"given":"Anna","family":"Bacchetti","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6678-7021","authenticated-orcid":false,"given":"Brenna","family":"McCormack","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9605-8095","authenticated-orcid":false,"given":"Ting-Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozita","family":"Doosti","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of 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