{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T13:46:07Z","timestamp":1764337567200,"version":"3.46.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Cedars-Sinai Women\u2019s Guild Neurology"},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"crossref","award":["HT9425-23-1-0571"],"award-info":[{"award-number":["HT9425-23-1-0571"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National MS Society","award":["RG-2110-38526"],"award-info":[{"award-number":["RG-2110-38526"]}]},{"name":"Erwin Rautenberg Foundation for Research Support"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Optic neuritis (ON) is a common manifestation of multiple sclerosis and related disorders (MSRD) characterized by retinal neurodegeneration, including thinning of ganglion cell-inner plexiform layer (GCIPL). Compared to absolute values, inter-eye differences (IED) account for variation in baseline structure and function before ON.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine retinal layer IED thresholds associated with multimodal visual dysfunction after unilateral demyelinating ON.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, MSRD participants with and without a history of unilateral ON, and healthy controls underwent optical coherence tomography, best-corrected visual acuity, 2.5% and 1.25% low-contrast letter acuity (LCLA), standard automated perimetry, and color vision testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty-six participants with MSRD (33 with unilateral ON history, 33 without ON history) and 15 healthy controls were included. For the ON cohort, a GCIPL IED threshold of 6.5% was associated with dyschromatopsia (AUC\u2009=\u20090.76,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.011), 11% with 1.25% LCLA IED of &gt;5 letters (AUC\u2009=\u20090.75,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.008), 13% with 2.5% LCLA IED of &gt;5 letters (AUC\u2009=\u20090.86,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), 15% with VFMD IED of &gt;2\u2005dB (AUC\u2009=\u20090.75,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.031), and 27% with logarithm of minimum angle of resolution IED of &gt;0.3 (AUC\u2009=\u20091.00,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). These associations were more robust compared to other retinal layer IED.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GCIPL IED thresholds more accurately reflect multimodal visual dysfunction after ON compared to other retinal layer IED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173251397302","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:57:49Z","timestamp":1764089869000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Retinal ganglion cell loss is associated with multimodal visual dysfunction following demyelinating optic neuritis"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3448-7930","authenticated-orcid":false,"given":"Mustafa","family":"Subhi","sequence":"first","affiliation":[{"name":"Cedars-Sinai Medical Center"},{"name":"Cedars-Sinai Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sargis","family":"Manukyan","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"},{"name":"Cedars-Sinai Medical Center"},{"name":"Cedars-Sinai Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Zabala","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"},{"name":"Cedars-Sinai Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Locke","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Kaisey","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afshin James","family":"Khodabakhsh","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Carass","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry L.","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-0714","authenticated-orcid":false,"given":"Shiv","family":"Saidha","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Calabresi","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy L.","family":"Sicotte","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6763-0125","authenticated-orcid":false,"given":"Pascal","family":"Sati","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"},{"name":"Cedars-Sinai Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2260-5660","authenticated-orcid":false,"given":"Omar","family":"Al-Louzi","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center"},{"name":"Cedars-Sinai Medical Center"},{"name":"Cedars-Sinai Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.CON.0000389938.07532.67"},{"key":"e_1_3_5_3_2","first-page":"30","article-title":"Ocular pain","volume":"16","author":"BLAK EV","year":"2009","unstructured":"BLAK EV. 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