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A subset of 15 participants had corresponding T\n                      <jats:sub>1<\/jats:sub>\n                      -maps at 7T. T\n                      <jats:sub>1<\/jats:sub>\n                      relaxation times were calculated in the normal-appearing cortex subjacent to the LME, in comparison to the adjacent and homologue cortex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      243 LME foci were found across 65 participants (73%). One hundred and sixty-one (66.3%) LME foci were posterior to the central sulcus. Three of 15 7T participants had a cortical lesion nearby LME (3\/49 foci). Mean T\n                      <jats:sub>1<\/jats:sub>\n                      times within cortex beneath LME (1734\u2009\u00b1\u2009135\u2005ms) were elevated compared to homologue (1668\u2009\u00b1\u2009167\u2005ms,\n                      <jats:italic toggle=\"yes\">p\u2009=\u2009<\/jats:italic>\n                      .0052) and adjacent cortex (1651\u2009\u00b1\u2009133\u2005ms,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Regional variations in LME distribution may point to topographical differences in the blood-meningeal barrier. Alterations in T\n                      <jats:sub>1<\/jats:sub>\n                      relaxation time observed in the cortex adjacent to LME may signify subtle tissue changes in the absence of cortical lesions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173251408625","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:03:48Z","timestamp":1768932228000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Leptomeningeal enhancement in multiple sclerosis demonstrates posterior predilection and T\n                    <sub>1<\/sub>\n                    alterations in the adjacent cortex"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1117-8987","authenticated-orcid":false,"given":"Ashley A.","family":"Thommana","sequence":"first","affiliation":[{"name":"Neuroimmunology Branch, National Institute 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