{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T21:43:09Z","timestamp":1769377389136,"version":"3.49.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Finnish MS Foundation"},{"DOI":"10.13039\/501100005433","name":"Pohjois-Pohjanmaan Rahasto","doi-asserted-by":"publisher","award":["60212346"],"award-info":[{"award-number":["60212346"]}],"id":[{"id":"10.13039\/501100005433","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005433","name":"Pohjois-Pohjanmaan Rahasto","doi-asserted-by":"publisher","award":["60221946"],"award-info":[{"award-number":["60221946"]}],"id":[{"id":"10.13039\/501100005433","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012682","name":"Oulun Yliopiston Tukis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["20230121"],"award-info":[{"award-number":["20230121"]}],"id":[{"id":"10.13039\/501100012682","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Finnish Neurological Society"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Comorbidities are common among people with multiple sclerosis (pwMS) and have been suggested to affect the usage of disease-modifying treatments (DMTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated the prevalence and types of comorbidities in newly diagnosed pwMS, as well as the associations between comorbidities and the choice and persistence of the initial DMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective register study used data from the Finnish MS register (85% of national coverage). The inclusion criteria were a diagnosis of relapsing-remitting MS between 2010 and 2022, the first DMT started between 2016 and 2022, and an age of at least 18 years. The exclusion criteria were a diagnosis of secondary progressive MS and initiation of azathioprine or mitoxantrone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The inclusion criteria were met by 1630 pwMS. At least one comorbidity was present in 50.9% of the pwMS. Respiratory comorbidities were associated with the choice of medium-efficacy DMT over high-efficacy DMT (OR = 0.58, CI\u2009=\u20090.36\u20130.91). Multicomorbidity was associated with lower persistence on all DMTs. Additionally, lower persistence on medium-efficacy DMTs was associated with autoimmune and psychiatric comorbidities and the injectable administration route.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Comorbidities are prevalent among newly diagnosed pwMS. Clinicians should consider comorbidities carefully, as they are associated with DMT persistence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173251411076","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T18:14:23Z","timestamp":1768414463000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comorbidities in newly diagnosed multiple sclerosis patients: A population-based register study in Finland"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3641-3504","authenticated-orcid":false,"given":"Henrik","family":"Ahvenj\u00e4rvi","sequence":"first","affiliation":[{"name":"University of Oulu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4346-1133","authenticated-orcid":false,"given":"Johanna","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"University of Oulu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2854-2410","authenticated-orcid":false,"given":"Matias","family":"Viitala","sequence":"additional","affiliation":[{"name":"StellarQ Ltd, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Jokinen","sequence":"additional","affiliation":[{"name":"Novartis Finland Ltd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Autio","sequence":"additional","affiliation":[{"name":"Novartis Finland Ltd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M","family":"Portaankorva","sequence":"additional","affiliation":[{"name":"University of Oulu"},{"name":"University of Helsinki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-0229","authenticated-orcid":false,"given":"Merja","family":"Soilu-H\u00e4nninen","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences, University of Turku, Turku, Finland; Neurocenter, Turku University Hospital, TYKS, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervi","family":"Ryytty","sequence":"additional","affiliation":[{"name":"University of Oulu"},{"name":"Oulu University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000442203"},{"key":"e_1_3_3_3_2","article-title":"Investigating the prevalence of comorbidity in multiple sclerosis clinical trial populations","volume":"102","author":"Salter A","unstructured":"Salter A, Lancia S, Kowalec K, et al. Investigating the prevalence of comorbidity in multiple sclerosis clinical trial populations. 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