{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T12:40:17Z","timestamp":1776516017888,"version":"3.51.2"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Norrbacka-Eugeniastiftelsen, Stockholm, Sweden"},{"name":"BiogenIdec Sweden AB, Sweden"},{"name":"The Research Committee of \u00d6rebro County Council, \u00d6rebro, Sweden"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple sclerosis (MS) is a progressive disease that may affect respiratory muscle function. Pulmonary dysfunction may be subclinical, and posture changes can reduce lung volumes, especially in the presence of respiratory muscle weakness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether lung function differs between sitting and supine positions in individuals with moderate MS, and to explore associations with respiratory muscle strength and disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty-eight participants with moderate MS (13 men, 35 women; median Expanded Disability Status Scale (EDSS) 4.5, range: 4.0\u20136.5) underwent spirometry (VC, FVC, FEV\n                      <jats:sub>1<\/jats:sub>\n                      , PEF) in sitting and supine positions. Respiratory muscle strength was assessed using maximal inspiratory (MIP) and expiratory pressures (MEP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      VC and FVC did not differ significantly between positions. FEV\n                      <jats:sub>1<\/jats:sub>\n                      and PEF were slightly reduced in the supine position (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009\u2264\u20090.001), with median relative decreases of \u22126% and \u221210%, respectively. These changes did not correlate with EDSS, MIP, or MEP. No sex-related differences were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      FEV\n                      <jats:sub>1<\/jats:sub>\n                      and PEF are reduced in the supine position in individuals with moderate MS, indicating early positional respiratory changes. These alterations appear independent of disability level or respiratory muscle strength. However, it remains uncertain whether these changes differ from those of healthy individuals. Controlled studies are warranted to clarify their clinical significance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173261443831","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T12:09:16Z","timestamp":1776341356000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative analysis of lung function in supine and sitting positions in patients with moderate multiple sclerosis"],"prefix":"10.1177","volume":"12","author":[{"given":"Joar","family":"Wikars","sequence":"first","affiliation":[{"name":"School of Health Sciences, Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareta","family":"K\u00e5n\u00e5hols","sequence":"additional","affiliation":[{"name":"\u00d6rebro University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ylva","family":"Nilsag\u00e5rd","sequence":"additional","affiliation":[{"name":"University Health Care Research Center, Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Gunnarsson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8363-1662","authenticated-orcid":false,"given":"Elisabeth","family":"Westerdahl","sequence":"additional","affiliation":[{"name":"University Health Care Research Center, Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"8","article-title":"Lung volume recruitment in multiple sclerosis","author":"Srour N","year":"2013","unstructured":"Srour N, LeBlanc C, King J, et al. 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