{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:12:37Z","timestamp":1783905157488,"version":"3.55.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009047","name":"Strategic Research Council","doi-asserted-by":"publisher","award":["358415"],"award-info":[{"award-number":["358415"]}],"id":[{"id":"10.13039\/501100009047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Fatigue and cognitive impairment are common in people with multiple sclerosis (pwMS). This study evaluated the feasibility of a digital symptom management program integrated into the Finnish MS Registry targeting fatigue and cognitive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Forty pwMS with subjective fatigue and cognitive concerns enrolled in an eight-session eHealth program including symptom self-assessments, a mobile fatigue diary, individualized goal setting, and feedback from a neuropsychologist. Feasibility outcomes were completion rate, perceived usefulness, and technical functionality. Patient-reported outcome measures (PROMs) included the Goal Attainment Scale (GAS), Global Rating of Change (GRC), Fatigue Scale for Motor and Cognitive Functions, Multiple Sclerosis Neuropsychological Questionnaire, patient-reported Expanded Disability Status Scale, Visual Analogue Scales for neurological symptoms, and EQ-5D-5L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-three participants (58%) completed the program with follow-up. The program was rated useful by 65% and technically appropriate by 70%. The mean GAS T-score was 50 both postintervention and at follow-up. Mean GRC scores indicated slightly positive change in managing fatigue (+1.4), cognitive symptoms (+1.3), and overall effects (+1.8). Other PROM changes were minimal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The registry-integrated eHealth program showed potential to support the management of fatigue and cognitive symptoms in pwMS. Further development and evaluation of digital symptom management tools are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173261453202","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:16:15Z","timestamp":1783606575000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of a registry-integrated eHealth program for managing fatigue and cognitive problems in multiple sclerosis"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-4650","authenticated-orcid":false,"given":"P\u00e4ivi","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"first","affiliation":[{"name":"StellarQ Ltd"},{"name":"Finnish Neuro Society, Masku, Finland"},{"name":"Department of Health and Social Management, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3697-4961","authenticated-orcid":false,"given":"Hanna","family":"Kuusisto","sequence":"additional","affiliation":[{"name":"Department of Health and Social Management, University of Eastern Finland, Kuopio, Finland"},{"name":"Tampere University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3769-5870","authenticated-orcid":false,"given":"Henriikka","family":"Nurmi","sequence":"additional","affiliation":[{"name":"StellarQ Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Avikainen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nova Hospital in Central Finland, Jyv\u00e4skyl\u00e4, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-0229","authenticated-orcid":false,"given":"Merja","family":"Soilu-H\u00e4nninen","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland"},{"name":"University of Turku"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3814-371X","authenticated-orcid":false,"given":"Mervi","family":"Ryytty","sequence":"additional","affiliation":[{"name":"Oulu University Hospital"},{"name":"University of Oulu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhani","family":"Ruutiainen","sequence":"additional","affiliation":[{"name":"University of Turku"},{"name":"Finnish Neuro Society, Masku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2015.1086362"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518769837"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/2055217318822134"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1191\/135248506ms1373ed"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/2055217321999826"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004977"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328346a43b"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12650"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104529"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12010055"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/20552173241272561"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520966300"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-024-01354-x"},{"key":"e_1_3_3_15_2","article-title":"Telerehabilitation for persons with multiple sclerosis","volume":"2015","author":"Khan F","year":"2015","unstructured":"Khan F, Amatya B, Kesselring J, et al. 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