{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:20:44Z","timestamp":1780323644015,"version":"3.54.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100019721","name":"Roche Espa\u00f1a","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>This study evaluated perceived workplace difficulties in 128 individuals with early-stage relapsing-remitting multiple sclerosis and low physical disability. Significant workplace challenges were reported by 40.6% of participants. External barriers, including workplace inflexibility and professional-domestic life imbalance (median 23-item multiple sclerosis (MS) Work Difficulties Questionnaire-MSWDQ-23 score: 31.3, interquartile range 6.3\u201356.3), represented the highest burden. Women reported higher difficulty scores than men (mean MSWDQ-23 total scores: 29.9 vs. 21.2, p\u2009=\u20090.010). Multivariable analysis identified fatigue (OR 1.37, 95% CI 1.17\u20131.61) and anxiety (OR 1.21, 95% CI 1.05\u20131.38) as the only independent predictors of significant workplace difficulty (p\u2009&lt;\u20090.001). These findings demonstrate a significant dissociation between physical disability and functional outcomes. Vocational vulnerability is driven by non-motor symptoms rather than overt neurological impairment. Proactive clinical screening for these factors is essential to mitigate work instability and preserve long-term professional trajectories.<\/jats:p>","DOI":"10.1177\/20552173261455229","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T15:17:04Z","timestamp":1780154224000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Workplace difficulties in early-stage relapsing-remitting multiple sclerosis with low physical disability"],"prefix":"10.1177","volume":"12","author":[{"given":"\u00c1ngel","family":"P\u00e9rez-Sempere","sequence":"first","affiliation":[{"name":"Department of Neurology, Hospital Universitario General de Alicante, Universidad Miguel Hern\u00e1ndez, Alicante, 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