{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T13:59:14Z","timestamp":1780840754962,"version":"3.54.1"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201554"],"award-info":[{"award-number":["82201554"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) differ substantially in pathophysiological mechanisms, clinical manifestations and therapeutic management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the disease burden of NMOSD and MS in South China and analyse the differences in disease burden between the two.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We extracted the demographic characteristics, diagnoses, duration of hospitalization and mortality from the direct reporting system of health information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2016 to 2022, the study identified 12,799 hospital admissions for 8204 patients with NMOSD and 6783 hospital admissions for 5125 patients with MS. The female-to-male ratio among patients with MS was 1.82. The peak age of NMOSD diagnosis was 45\u201355 years. The peak age of MS diagnosis was 25\u201335 years. The average duration of hospitalization for patients with NMOSD was 12 (7\u201317) days, whereas that for patients with MS was 10 (6\u201314) days. The percentage of NMOSD admissions to the intensive care unit was higher than that of MS admissions. The mortality rate for both NMOSD and MS was 0.2%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In South China, the disease burden of NMOSD is heavier than that of MS. The NMOSD exhibited a higher number of cases, longer duration of hospitalization and more severe clinical conditions than MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173261457757","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:00:50Z","timestamp":1780664450000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences in disease burden between neuromyelitis optica spectrum disorder and multiple sclerosis in South China"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3780-6422","authenticated-orcid":false,"given":"Xin","family":"Huang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital, Sun Yat-sen University"},{"name":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyu","family":"Feng","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Sun Yat-sen University"},{"name":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Sun Yat-sen University"},{"name":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Fan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological 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