{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:01:39Z","timestamp":1784988099129,"version":"3.55.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple sclerosis (MS) monitoring often relies on traditional methods like the expanded disability status scale (EDSS) and magnetic resonance imaging, which may not fully reflect patients\u2019 health. Patient-reported outcomes (PROs) provide valuable insights into patients\u2019 experiences of their disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study evaluated the Danish implementation of PROs for people with MS (PwMS) 3 years post-launch, comparing clinical and demographic characteristics between PRO users and non-users, and assessing PRO adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>As of 1 January 2025, 2121 PwMS had signed up for PRO, compared to 14,125 who did not. PRO users were younger (mean age 50.6 vs. 53.2 years), more frequently female (73.6% vs. 68.0%), had a shorter disease duration (15.1 vs. 16.4 years), and were more likely to be on high-efficacy disease-modifying therapies (75.6% vs. 62.2%). Additionally, fewer PRO users had low EDSS scores (&lt;3, 53.7% vs. 56.1%) and high scores (&gt;6, 16.5% vs. 18.9%). Most enrolled patients lived in Region Hovedstaden (75.1%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study highlights differences in profile between PRO users and non-users, demonstrating the PRO platform's adaptability across different ages and disability levels in PwMS. However, these findings also highlight potential implementation challenges and emphasize the need for sustained commitment to support long-term use of PRO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173261468115","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:37:35Z","timestamp":1784813855000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights from a Danish nationwide implementation of patient-reported outcomes in multiple sclerosis"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-0228","authenticated-orcid":false,"given":"Rolf Pringler","family":"Holm","sequence":"first","affiliation":[{"name":"Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital \u2013Rigshospitalet, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-3827","authenticated-orcid":false,"given":"Luigi","family":"Pontieri","sequence":"additional","affiliation":[{"name":"Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital \u2013Rigshospitalet, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-8220","authenticated-orcid":false,"given":"Mie Reith","family":"Mahler","sequence":"additional","affiliation":[{"name":"Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital \u2013Rigshospitalet, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Joensen","sequence":"additional","affiliation":[{"name":"Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital \u2013Rigshospitalet, Glostrup, 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Danish Multiple Sclerosis Society, Valby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Sejbaek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Esbjerg Hospital, University Hospital of Southern Denmark, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Kahr","family":"Mathiesen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Copenhagen University Hospital Herlev and Gentofte, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Bang","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital North Zeeland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrin","family":"Asgari","sequence":"additional","affiliation":[{"name":"Slagelse Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Vestergaard","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Leif Munding","family":"Stilund","sequence":"additional","affiliation":[{"name":"G\u00f8dstrup Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe Gro","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital \u2013 Rigshospitalet, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Bramow","sequence":"additional","affiliation":[{"name":"Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University 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