{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:14:36Z","timestamp":1788239676648,"version":"build-2803163510"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Hideyuki Takeuchi","award":["JPMH23FC1009"],"award-info":[{"award-number":["JPMH23FC1009"]}]},{"name":"Hideyuki Takeuchi","award":["JSPS24K10626"],"award-info":[{"award-number":["JSPS24K10626"]}]},{"name":"Yoshihisa Yamano","award":["AMED, JP23ek0109529h"],"award-info":[{"award-number":["AMED, JP23ek0109529h"]}]},{"name":"Yoshihisa Yamano","award":["AMED, JP23ek0109548s"],"award-info":[{"award-number":["AMED, JP23ek0109548s"]}]},{"name":"Yoshihisa Yamano","award":["JPMH22FC1013"],"award-info":[{"award-number":["JPMH22FC1013"]}]},{"name":"Yoshihisa Yamano","award":["JSPS22H02987"],"award-info":[{"award-number":["JSPS22H02987"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Evidence regarding neonatal immune outcomes following late-gestation exposure to ofatumumab remains limited. We report a 35-year-old woman with relapsing multiple sclerosis who continued ofatumumab until 28 weeks of gestation following individualized shared decision-making based on informed patient preference. The patient remained clinically and radiologically stable throughout pregnancy. Sustained maternal B-cell depletion enabled early postpartum resumption of maintenance therapy without re-induction. Although neonatal immune status at birth was unavailable, her infant showed normal B-cell counts during follow-up and completed routine vaccinations, including live vaccines, without complications. This case provides clinically relevant longitudinal neonatal immune and vaccination data following late-gestation ofatumumab exposure.<\/jats:p>","DOI":"10.1177\/20552173261472641","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:10:02Z","timestamp":1786630202000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Continuous ofatumumab treatment until the early third trimester in multiple sclerosis with preserved neonatal immunity"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9516-6753","authenticated-orcid":false,"given":"Kenzo","family":"Sakurai","sequence":"first","affiliation":[{"name":"St Marianna University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5912-7581","authenticated-orcid":false,"given":"Hideyuki","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine, International University of Health and Welfare"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3889-2449","authenticated-orcid":false,"given":"Tomohiro","family":"Katsuta","sequence":"additional","affiliation":[{"name":"St Marianna University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Aiba","sequence":"additional","affiliation":[{"name":"St Marianna University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Shibata","sequence":"additional","affiliation":[{"name":"St Marianna University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Kaburagi","sequence":"additional","affiliation":[{"name":"St Marianna University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"St Marianna University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Takao","sequence":"additional","affiliation":[{"name":"St Marianna University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7527-0345","authenticated-orcid":false,"given":"Yoshihisa","family":"Yamano","sequence":"additional","affiliation":[{"name":"St Marianna University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-023-00518-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-025-00784-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/pn-2022-003426"},{"key":"e_1_3_3_5_2","unstructured":"European Medicines Agency. Kesimpta (ofatumumab) EPAR. 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