{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:29:38Z","timestamp":1786123778572,"version":"build-2736575974"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100018892","name":"F\u00f6rs\u00e4kringskassan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Family planning and treatment management in women with multiple sclerosis (MS) require complex decision-making. In most cases, patients express their intention to start a family, giving physicians time to monitor their MS and align treatment plans accordingly. However, not all pregnancies are planned, which can make timely communication with healthcare providers challenging. This study explores the dynamics between patients and healthcare professionals in MS care, focusing on family planning and treatment decisions before, during, and after pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>People with MS aged 20\u201350 in the Swedish MS register (SMSreg) were invited to participate in an online survey in 2021. Responses of 3078 women were linked to SMSreg and other national register datasets. Descriptive statistics and multinomial logistic regression explored information sources, care, family planning discussion, treatment satisfaction, and its impact on their disease and breastfeeding decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Women with MS reported receiving annual care from a neurologist (88%), nurse (68%) or general practitioner (46%), with satisfaction ranging from 40\u201377%. Most were treated with high efficacy (HE) disease-modifying treatments (DMTs) (66%), of whom 49% used rituximab. Treatment satisfaction was higher among younger women, milder EDSS, and those on HE DMTs. Women who became pregnant after their MS diagnosis (41%) were more likely to have discussed family planning with a physician (78%) compared to those who had not been pregnant post-diagnosis (59%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In Sweden, women with MS generally have regular contact with healthcare professionals, though satisfaction varies. Family planning discussions were more frequent among women who became pregnant after diagnosis, highlighting the importance of proactive communication. Treatment choices influence both satisfaction and reproductive decisions, underscoring the need for clear guidance and shared decision-making. Real-world data also indicate that rituximab is commonly used during peripregnancy, likely due to its favourable safety profile and long-lasting effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173261472661","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:35:10Z","timestamp":1785944110000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Family planning and multiple sclerosis \u2013 Part 1: Patient perspectives on treatment choices in Sweden"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8957-661X","authenticated-orcid":false,"given":"Alejandra","family":"Machado","sequence":"first","affiliation":[{"name":"Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4776-9162","authenticated-orcid":false,"given":"Emma","family":"Pettersson","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6182-499X","authenticated-orcid":false,"given":"Fitsum Sebsibe","family":"Teni","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Fink","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7874-4243","authenticated-orcid":false,"given":"Emilie","family":"Friberg","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"493","article-title":"Multiple sclerosis in pregnancy and its role in female fertility: a systematic review","volume":"25","author":"Lamaita R","year":"2021","unstructured":"Lamaita R, Melo C, Laranjeira C, et al. Multiple sclerosis in pregnancy and its role in female fertility: a systematic review. JBRA Assist Reprod 2021; 25: 493\u2013499.","journal-title":"JBRA Assist Reprod"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000731"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000001108"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006384"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.101137"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00426-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6653-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102694"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09913-1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/21556660.2020.1721507"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000200253"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000745"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.06.006"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.620772"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807303390501"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009374"},{"key":"e_1_3_3_18_2","unstructured":"National Board of Health and Welfare [Socialstyrelsen] Nationella riktlinjer: v\u00e5rd vid multipel skleros och Parkinsons sjukdom \u2013 st\u00f6d f\u00f6r styrning och ledning [National guidelines for care in multiple sclerosis and Parkinson's disease: support for steering and management]. Stockholm: Socialstyrelsen; 2022 [cited 2026 Jan 28]. Available from: https:\/\/www.socialstyrelsen.se\/kunskapsstod-och-regler\/regler-och-riktlinjer\/nationella-riktlinjer\/riktlinjer-och-utvarderingar\/ms-och-parkinsons-sjukdom\/om-riktlinjerna-for-patienter\/."},{"key":"e_1_3_3_19_2","unstructured":"Fink K. Behandlingsrekommendationer f\u00f6r kvinnor med MS i barnaf\u00f6dande \u00e5lder [Treatment recommendations for women with MS of childbearing age]. In: METODBOK MS. Stockholm: Svenska MS s\u00e4llskapet [Swedish MS Society]; 2024. [cited 2026 Jan 28]. Available from: https:\/\/www.mssallskapet.se\/metodbok\/."},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12963"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4011"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003331"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000208063"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26914"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000903"},{"key":"e_1_3_3_26_2","article-title":"Pregnancy outcomes following maternal treatment with rituximab prior to or during pregnancy: a case series","volume":"5","author":"Perrotta K","year":"2021","unstructured":"Perrotta K, Kiernan E, Bandoli G, et al. Pregnancy outcomes following maternal treatment with rituximab prior to or during pregnancy: a case series. 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