{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:37:59Z","timestamp":1786451879911,"version":"build-2736575974"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pathophysiological drivers of sex differences in multiple sclerosis (MS) remain unclear. Potential candidates include bioactive lipid mediators (LMs), which are pivotal regulators of neuro-inflammatory responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate sex-dependent LM differences in MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma lipids were measured using targeted HPLC-MS\/MS in a birth-year MS cohort (N\u2009=\u2009410; n\u2009=\u2009285 MS, n\u2009=\u2009169 RRMS, n\u2009=\u200980 SPMS and n\u2009=\u200936 PPMS). Lipid profiles were compared between sexes and correlated with disability (Expanded Disability Status Scale (EDSS)), neuroaxonal damage (neurofilament light, NfL), whole brain volume (WBV) and T2 lesion volume (LV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In healthy controls, 9-HOTrE levels were higher in women than men. In individuals with MS, women had higher 9-HOTrE, 18-HEPE and 9-HODE levels than men, while men had higher 15-HEPE, 17-HDHA and 11,12-DiHET levels than women. Among these LMs, increased 11,12-DiHET levels were associated with higher EDSS and NfL levels, while higher levels of the remaining LMs, such as 9-HOTrE, were associated with lower EDSS and lower LV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings provide insights into potential sex-dependent lipid-mediated pathophysiological mechanisms in MS patients. Our findings suggest that certain LMs, such as 9-HOTrE, may display neuroprotective effects in MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173261475501","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T17:50:12Z","timestamp":1786211412000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex-dependent bioactive lipid mediator profiles in multiple sclerosis"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8908-8553","authenticated-orcid":false,"given":"Wing Hee","family":"Fung","sequence":"first","affiliation":[{"name":"Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc"},{"name":"Amsterdam UMC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-1127","authenticated-orcid":false,"given":"Serhii","family":"Chornyi","sequence":"additional","affiliation":[{"name":"Amsterdam UMC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-6959","authenticated-orcid":false,"given":"Menno M","family":"Schoonheim","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9226-7364","authenticated-orcid":false,"given":"Bernard MJ","family":"Uitdehaag","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-5957","authenticated-orcid":false,"given":"Joep","family":"Killestein","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6705-5864","authenticated-orcid":false,"given":"Eva MM","family":"Strijbis","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-2918","authenticated-orcid":false,"given":"Gijs","family":"Kooij","sequence":"additional","affiliation":[{"name":"Amsterdam UMC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073-13.2.65"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(07)79019-0"},{"key":"e_1_3_3_4_2","unstructured":"Filiberto AC Leroy V Ladd Z et al. 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Neuroaxonal and glial markers in patients of the same age with multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 2023: 10: e200078.","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104568"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168188"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2018.08.003"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.05.008"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16009"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.65"},{"key":"e_1_3_3_21_2","first-page":"15","article-title":"Sex-specific response of the brain free oxylipin profile to soluble epoxide hydrolase inhibition","author":"Norman JE","year":"2023","unstructured":"Norman JE, Nuthikattu S, Milenkovic D, et al. 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