{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T07:42:00Z","timestamp":1786261320148,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"GAIA AG"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis Journal \u2013 Experimental, Translational and Clinical"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People with multiple sclerosis (pwMS) often experience impaired quality of life (QoL) despite receiving standard care. Digital therapeutics (DTx) may offer support, but prior trials yielded mixed results, possibly due to active controls and high baseline QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We evaluated a DTx (levidex) as an adjunct to treatment as usual (TAU) in pwMS with impaired QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this pragmatic, online randomized controlled trial (LAMONT; NCT06090305),\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009470 pwMS with a score\u2009\u2265\u20092 on the Hamburg Quality of Life Questionnaire in Multiple Sclerosis (HAQUAMS) were randomized to levidex\u2009+\u2009TAU or TAU alone. The primary endpoint was HAQUAMS total score at 6 months, analysed by intention-to-treat analysis of covariance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with TAU, levidex\u2009+\u2009TAU improved multiple sclerosis-specific QoL at 6 months (baseline-adjusted mean difference \u22120.10; 95% CI \u22120.18 to \u22120.03;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.008; Cohen's\n                      <jats:italic toggle=\"yes\">d<\/jats:italic>\n                      \u2009=\u20090.26). Clinically relevant HAQUAMS improvement (\u22650.22) occurred more often with levidex (39.5% vs. 27.8%; number needed to treat\u2009=\u20099). Benefits also emerged for depressive symptoms and social\/work functioning but not for anxiety. No serious adverse events occurred, and user satisfaction was high.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In pwMS with impaired QoL, adding the scalable DTx levidex to TAU yields meaningful improvements in QoL and functioning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20552173261475519","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:15:40Z","timestamp":1786025740000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of a digital health application (\n                    <i>levidex<\/i>\n                    ) on quality of life in people with multiple sclerosis: A pragmatic, randomized controlled trial (LAMONT)"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-0260","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Meyer","sequence":"first","affiliation":[{"name":"GAIA Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gereon","family":"Nelles","sequence":"additional","affiliation":[{"name":"Neuromed-Campus Hohenlind"},{"name":"Medizinische Fakult\u00e4t, Universit\u00e4t Duisburg-Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1741-4069","authenticated-orcid":false,"given":"Linda","family":"Betz","sequence":"additional","affiliation":[{"name":"GAIA Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnfin","family":"Bergmann","sequence":"additional","affiliation":[{"name":"NeuroTransData"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Jauch-Chara","sequence":"additional","affiliation":[{"name":"Psychiatry, Psychosomatic Medicine and Psychotherapy, Vincera Kliniken Bad Waldsee, Bad Waldsee, DE, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6681-7054","authenticated-orcid":false,"given":"Nicole","family":"Krause","sequence":"additional","affiliation":[{"name":"University Medical Center Hamburg-Eppendorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-2640","authenticated-orcid":false,"given":"Karin","family":"Riemann","sequence":"additional","affiliation":[{"name":"University Medical Center Hamburg-Eppendorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3820-9059","authenticated-orcid":false,"given":"Barbara","family":"von Glasenapp","sequence":"additional","affiliation":[{"name":"University Medical Center Hamburg-Eppendorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-9467","authenticated-orcid":false,"given":"Christoph","family":"Heesen","sequence":"additional","affiliation":[{"name":"University Medical Center Hamburg-Eppendorf"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520970841"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-041249"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-021-00239-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1286122"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291724001995"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073.2020-026"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231201089"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/17562864221118729"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-024-03843-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585251356410"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03434-w"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1635872"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/135245850100700208"},{"key":"e_1_3_3_15_2","unstructured":"LimeSurvey: An open source survey tool (Internet). https:\/\/www.limesurvey.org (2024)."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317463"},{"key":"e_1_3_3_17_2","article-title":"Internet-delivered cognitive behavioural therapy programme to reduce depressive symptoms in patients with multiple sclerosis: A multicentre, randomised, controlled, phase 3 trial","volume":"5","author":"Gold SM","year":"2023","unstructured":"Gold SM, Friede T, Meyer B, et al. 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