{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:20:51Z","timestamp":1777864851225,"version":"3.51.4"},"reference-count":63,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["#1017607"],"award-info":[{"award-number":["#1017607"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Rehabilitation and Assistive Technologies Engineering"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The patient\u2019s voice in shared decision-making has progressed from physician\u2019s office to regulatory decision-making for medical devices with FDA\u2019s Patient Preference Initiative. A discrete-choice preference measure for upper limb prosthetic devices was developed to investigate patient\u2019s risk\/benefit preference choices for regulatory decision making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rapid ethnographic procedures were used to design a discrete-choice measure describing risk and benefits of osseointegration with myoelectric control and test in a pilot preference study in adults with upper limb loss. Primary outcome is utility of each choice based conjoint (CBC) attribute using mixed-effects regression. Utilities with and without video, and between genders were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Strongest negative preference was for avoiding infection risk (B = \u22121.77, p &lt; 0.001) and chance of daily pain (B = \u22121.22, p, 0.001). Strongest positive preference was for attaining complete independence when cooking dinner (B = 1.62, p &lt; 0.001) and smooth grip patterns at all levels (B = 1.62, B = 1.28, B = 1.26, p &lt; 0.001). Trade-offs showed a 1% increase in risk of serious\/treatable infection resulted in a 1.77 decrease in relative preference. There were gender differences, and where video was used, preferences were stronger.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Strongest preferences were for attributes of functionality and independence versus connectedness and sensation but showed willingness to make risk-benefit trade-offs. Findings provide valuable information for regulatory benefit-risk decisions for prosthetic device innovations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This study is not a clinical trial reporting results of a health care intervention so is not registered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20556683231152418","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T05:48:03Z","timestamp":1674193683000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prosthesis preferences for those with upper limb loss: Discrete choice study of PULLTY\u00ae for use in regulatory decisions"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3305-8730","authenticated-orcid":false,"given":"Leslie","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Cllinical Pharmacy, University of California San Francisco School of Pharmacy, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Dohan","sequence":"additional","affiliation":[{"name":"Institute for Health Policy Studies, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Garibaldi","sequence":"additional","affiliation":[{"name":"Director, Orthotics Prosthetics, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Szeto","sequence":"additional","affiliation":[{"name":"Department of Cllinical Pharmacy, University of California San Francisco School of Pharmacy, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly","family":"Timmerman","sequence":"additional","affiliation":[{"name":"General Physical Medicine & Rehabilitation, VA Palo Alto Health Care System, Palo Alto, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Matheny","sequence":"additional","affiliation":[{"name":"Department of Cllinical Pharmacy, University of California San Francisco School of Pharmacy, San Francisco, CA, 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