{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:15:35Z","timestamp":1792138535864,"version":"4.4.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiologica Open"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>The magnetic resonance imaging (MRI) appearance of an \u201cestablished\u201d bone marrow infarct is well-known, consisting of an area of preserved bone marrow signal surrounded by a serpiginous line. We report the uncommon observation of the very early phases of appearance of a bone marrow infarct, showing its progressive de novo appearance on MR images paralleling clinical symptoms and high-dose systemic steroid administration in a young female patient, presenting with acute knee pain. The initial knee MR examination performed one week after pain onset showed no abnormality. One week later, a second examination showed subtle ill-defined dotted signal abnormalities of the bone marrow of uncertain significance, of high signal on PDFS sequences. A third MR study obtained again one week later showed more evident findings with confluence of the high signal \u201cdots\u201d into a serpiginous line with a geographical appearance of the lesion, corresponding to the typical MRI presentation of bone marrow infarcts. Follow-up MRI at seven weeks showed definitive stability of this bone marrow infarct. A whole-body MRI performed for whole skeleton screening revealed multiple bone marrow infarcts typical for systemic avascular necrosis. This case represents a novel observation of the \u201cbirth\u201d of a bone marrow infarct, from early intriguing changes to its typical ring-shaped appearance on MR images. It also reminds of the key role of MRI for early diagnosis of bone marrow infarcts and illustrates the emerging role of whole-body MRI for the detection of multifocal, asymptomatic skeletal involvement by ischemic lesions in systemic osteonecrosis.<\/jats:p>","DOI":"10.1177\/2058460119834691","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:41:24Z","timestamp":1553733684000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["The \u201cbirth of death\u201d: MRI step-by-step reveals the early appearance of a bone marrow infarct"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0419-3383","authenticated-orcid":false,"given":"Elie","family":"Barakat","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Guischer","sequence":"additional","affiliation":[{"name":"Cliniques universitaires Saint-Luc, Institut de recherche exp\u00e9rimentale et clinique, Universit\u00e9 Catholique de Louvain, Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Houssiau","sequence":"additional","affiliation":[{"name":"Cliniques universitaires Saint-Luc, Institut de recherche exp\u00e9rimentale et clinique, Universit\u00e9 Catholique de Louvain, Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic E.","family":"Lecouvet","sequence":"additional","affiliation":[{"name":"Cliniques universitaires Saint-Luc, Institut de recherche exp\u00e9rimentale et clinique, Universit\u00e9 Catholique de Louvain, Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"bibr1-2058460119834691","doi-asserted-by":"publisher","DOI":"10.1148\/rg.344140019"},{"key":"bibr2-2058460119834691","unstructured":"Resnick D, Niwayama G. 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