{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:56:00Z","timestamp":1777434960745,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiologica Open"],"published-print":{"date-parts":[[2025,2]]},"abstract":"\n Background<\/jats:title>\n The left piriform cortex and amygdala (PC&A) tend to be slightly hyperintense relative to the right PC&A on T2-weighted fluid-attenuated inversion recovery (T2W-FLAIR) images in patients with probable Alzheimer\u2019s disease (pAD). This likely represents the antecedent and thus advanced degeneration of the left PC&A.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To investigate the relationship between left PC&A hyperintensities and cerebral cortical atrophy on magnetic resonance (MR) voxel-based morphometry in patients with pAD and discuss how this finding could relate to AD progression.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n Patients with pAD ( n = 47; age range = 68\u201393\u00a0years, mean = 80.8 \u00b1 6.7\u00a0years; 14 men and 33 women) who underwent T2W-FLAIR imaging and MR morphometric study using a voxel-based specific regional analysis system for AD (VSRAD) were retrospectively examined. To measure signal intensity ratios of the left to right PC&A (L-PC&A\/R-PC&A), regions of interest (ROIs) were set on the transaxial images in which both PC&As were most broadly depicted; the ROIs were defined as large as possible. Correlations between the L-PC&A\/R-PC&A and medial temporal lobe cortical atrophy (MTLCA) as well as whole cerebral cortical atrophy (WCCA) on VSRAD were determined. Correlation between the L-PC&A\/R-PC&A and age was also determined.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The L-PC&A\/R-PC&A correlated with both MTLCA (r = 0.375, p = .010, 95% confidence interval [CI] = 0.095\u20130.600) and WCCA (r = 0.576, p < .001, 95% CI = 0.343\u20130.742). The L-PC&A\/R-PC&A did not correlate with age (r = 0.013, p = .932, 95% CI = \u22120.282\u20130.305).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Left-sided dominance of PC&A degeneration appeared to accelerate with the progression of AD stages.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/20584601251317629","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T08:37:02Z","timestamp":1738658222000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperintensity of the left piriform cortex and amygdala on T2-weighted FLAIR images in patients with probable Alzheimer\u2019s disease correlates with cerebral cortical atrophy"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2461-7764","authenticated-orcid":false,"given":"Hiroshi","family":"Ishizaka","sequence":"first","affiliation":[{"name":"Department of Radiology, Maebashi Red Cross Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Sekine","sequence":"additional","affiliation":[{"name":"Department of Neurology, Maebashi Red Cross Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Naka","sequence":"additional","affiliation":[{"name":"Department of Radiology, Maebashi Red Cross Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Maebashi Red Cross Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nagase","sequence":"additional","affiliation":[{"name":"Department of Radiology, Maebashi Red Cross Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Tsushima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Medicine, Graduate School of Medicine, Gunma University, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"bibr1-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-005-0025-5"},{"key":"bibr2-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.09.006"},{"key":"bibr3-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617703930116"},{"key":"bibr4-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21057-y"},{"key":"bibr5-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22157"},{"key":"bibr6-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-010-9175-1"},{"key":"bibr7-20584601251317629","unstructured":"Ishizaka H, Sekine A, Naka M, et al. Slight hyperintensity of the left piriform cortex and amygdala on T2-weighted FLAIR images in older adults and patients with probable Alzheimer\u2019s disease (Under revision in Acta Radiologica)."},{"key":"bibr8-20584601251317629","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10040742"},{"key":"bibr9-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016152244"},{"key":"bibr10-20584601251317629","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216288"},{"key":"bibr11-20584601251317629","first-page":"29","volume":"4","author":"Matsuda H","year":"2013","journal-title":"Aging Dis"},{"key":"bibr12-20584601251317629","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2935"},{"key":"bibr13-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12370"},{"key":"bibr14-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520917270"},{"key":"bibr15-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"bibr16-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"bibr17-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14856"},{"key":"bibr18-20584601251317629","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-021-01146-y"},{"key":"bibr19-20584601251317629","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-142292"}],"container-title":["Acta Radiologica Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20584601251317629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20584601251317629","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20584601251317629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:55:11Z","timestamp":1777377311000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20584601251317629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/20584601251317629"],"URL":"https:\/\/doi.org\/10.1177\/20584601251317629","relation":{},"ISSN":["2058-4601","2058-4601"],"issn-type":[{"value":"2058-4601","type":"print"},{"value":"2058-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"article-number":"20584601251317629"}}